To compare: The protein import into the ER and into the nucleus. Concept introduction: For the proteins to import into the nucleus, the nuclear localization signal or sequence must tag the protein to be imported. Importin proteins will be present to bind the cargo protein so that they can interact with the nuclear pore complex and can pass through the channel. The protein import into the ER occurs co-translationally by the ribosomes on the ER with the translated protein going through a protein pore called translocator.

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Answer 1

Question

Chapter 15, Problem 16Q

Summary Introduction

To compare: The protein import into the ER and into the nucleus.

Concept introduction: For the proteins to import into the nucleus, the nuclear localization signal or sequence must tag the protein to be imported. Importin proteins will be present to bind the cargo protein so that they can interact with the nuclear pore complex and can pass through the channel. The protein import into the ER occurs co-translationally by the ribosomes on the ER with the translated protein going through a protein pore called translocator.

Summary Introduction

To explain: The reason that the ER mechanism might not work for nuclear import and vice versa.

Concept introduction: For the proteins to import into the nucleus, the nuclear localization signal or sequence must tag the protein to be imported. Importin proteins will be present to bind the cargo protein so that they can interact with the nuclear pore complex and can pass through the channel. The protein import into the ER occurs co-translationally by the ribosomes on the ER with the translated protein going through a protein pore called translocator.

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19. On the diagram below a. Label the three pictures as: DNA; polypeptide; or RNA. b. Label the arrows as: translation or transcription/RNA processing. c. Add the following details to the diagram. Promoter region TATA box Transcription start site Transcription terminator Intron (A,B,C,D) Exons (1,2,3,4,5) Splice sites 5' cap 5' UTR (untranslated region) 3' poly A tail 3' UTR (untranslated region) Translational start (AUG) Translational stop (UGA, UAG, or UAA) N and C ends of polypeptide 0000

Match the letter labels in the figure below to the terms. Some letter labels are not used. MNNNNNNIN M C B A M D F E H K G 8

The diagram below illustrates a quorum sensing pathway from Staphylococcus aureus. Please answer the following questions. 1. Autoinduction is part of the quorum sensing system. Which promoter (P2 or P3) is critical for autoinduction? 2)This staphylococcus aureus grows on human wounds, causing severe infections. You would like to start a clinical trial to treat these wound infections. Please describe: a) What molecule do you recommend for the trial. Why? b) Your trial requires that Staphylococcus aureus be isolated from the wound and submitted to genome sequencing before admittance. Why? What are you testing for? 3) If a mutation arises where the Promoter P3 is constitutively active, how would that influence sensitivity to AIP? Please explain your rationale. 4) This pathway is sensitive to bacterial cell density. Describe two separate mutation that would render the pathway active independent of cell density. Briefly explain your rationale. Mutation 1 Mutation 2

Answer 2

Question

Chapter 15, Problem 16Q

Summary Introduction

To compare: The protein import into the ER and into the nucleus.

Concept introduction: For the proteins to import into the nucleus, the nuclear localization signal or sequence must tag the protein to be imported. Importin proteins will be present to bind the cargo protein so that they can interact with the nuclear pore complex and can pass through the channel. The protein import into the ER occurs co-translationally by the ribosomes on the ER with the translated protein going through a protein pore called translocator.

Summary Introduction

To explain: The reason that the ER mechanism might not work for nuclear import and vice versa.

Concept introduction: For the proteins to import into the nucleus, the nuclear localization signal or sequence must tag the protein to be imported. Importin proteins will be present to bind the cargo protein so that they can interact with the nuclear pore complex and can pass through the channel. The protein import into the ER occurs co-translationally by the ribosomes on the ER with the translated protein going through a protein pore called translocator.

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Answer 3

Question

Chapter 15, Problem 16Q

Summary Introduction

To compare: The protein import into the ER and into the nucleus.

Concept introduction: For the proteins to import into the nucleus, the nuclear localization signal or sequence must tag the protein to be imported. Importin proteins will be present to bind the cargo protein so that they can interact with the nuclear pore complex and can pass through the channel. The protein import into the ER occurs co-translationally by the ribosomes on the ER with the translated protein going through a protein pore called translocator.

Summary Introduction

To explain: The reason that the ER mechanism might not work for nuclear import and vice versa.

Concept introduction: For the proteins to import into the nucleus, the nuclear localization signal or sequence must tag the protein to be imported. Importin proteins will be present to bind the cargo protein so that they can interact with the nuclear pore complex and can pass through the channel. The protein import into the ER occurs co-translationally by the ribosomes on the ER with the translated protein going through a protein pore called translocator.

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Answer 4

Question

Chapter 15, Problem 16Q

Summary Introduction

To compare: The protein import into the ER and into the nucleus.

Concept introduction: For the proteins to import into the nucleus, the nuclear localization signal or sequence must tag the protein to be imported. Importin proteins will be present to bind the cargo protein so that they can interact with the nuclear pore complex and can pass through the channel. The protein import into the ER occurs co-translationally by the ribosomes on the ER with the translated protein going through a protein pore called translocator.

Summary Introduction

To explain: The reason that the ER mechanism might not work for nuclear import and vice versa.

Concept introduction: For the proteins to import into the nucleus, the nuclear localization signal or sequence must tag the protein to be imported. Importin proteins will be present to bind the cargo protein so that they can interact with the nuclear pore complex and can pass through the channel. The protein import into the ER occurs co-translationally by the ribosomes on the ER with the translated protein going through a protein pore called translocator.

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Answer 5

Chapter 15, Problem 16Q

Summary Introduction

To compare: The protein import into the ER and into the nucleus.

Concept introduction: For the proteins to import into the nucleus, the nuclear localization signal or sequence must tag the protein to be imported. Importin proteins will be present to bind the cargo protein so that they can interact with the nuclear pore complex and can pass through the channel. The protein import into the ER occurs co-translationally by the ribosomes on the ER with the translated protein going through a protein pore called translocator.

Summary Introduction

To explain: The reason that the ER mechanism might not work for nuclear import and vice versa.

Concept introduction: For the proteins to import into the nucleus, the nuclear localization signal or sequence must tag the protein to be imported. Importin proteins will be present to bind the cargo protein so that they can interact with the nuclear pore complex and can pass through the channel. The protein import into the ER occurs co-translationally by the ribosomes on the ER with the translated protein going through a protein pore called translocator.

Answer 6

Chapter 15, Problem 16Q

Summary Introduction

To compare: The protein import into the ER and into the nucleus.

Concept introduction: For the proteins to import into the nucleus, the nuclear localization signal or sequence must tag the protein to be imported. Importin proteins will be present to bind the cargo protein so that they can interact with the nuclear pore complex and can pass through the channel. The protein import into the ER occurs co-translationally by the ribosomes on the ER with the translated protein going through a protein pore called translocator.

Answer 7

Chapter 15, Problem 16Q

Summary Introduction

To compare: The protein import into the ER and into the nucleus.

Concept introduction: For the proteins to import into the nucleus, the nuclear localization signal or sequence must tag the protein to be imported. Importin proteins will be present to bind the cargo protein so that they can interact with the nuclear pore complex and can pass through the channel. The protein import into the ER occurs co-translationally by the ribosomes on the ER with the translated protein going through a protein pore called translocator.

Answer 8

Summary Introduction

To explain: The reason that the ER mechanism might not work for nuclear import and vice versa.

Concept introduction: For the proteins to import into the nucleus, the nuclear localization signal or sequence must tag the protein to be imported. Importin proteins will be present to bind the cargo protein so that they can interact with the nuclear pore complex and can pass through the channel. The protein import into the ER occurs co-translationally by the ribosomes on the ER with the translated protein going through a protein pore called translocator.

Answer 9

Summary Introduction

To explain: The reason that the ER mechanism might not work for nuclear import and vice versa.

Concept introduction: For the proteins to import into the nucleus, the nuclear localization signal or sequence must tag the protein to be imported. Importin proteins will be present to bind the cargo protein so that they can interact with the nuclear pore complex and can pass through the channel. The protein import into the ER occurs co-translationally by the ribosomes on the ER with the translated protein going through a protein pore called translocator.

Answer 10

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Ch. 15 - Prob. 1Q Ch. 15 - Prob. 2Q Ch. 15 - Prob. 3Q Ch. 15 - Prob. 4Q Ch. 15 - Prob. 5Q Ch. 15 - Prob. 6Q Ch. 15 - Prob. 7Q Ch. 15 - Prob. 8Q Ch. 15 - Prob. 9Q Ch. 15 - Prob. 10Q

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