Chapter 15, Problem 14P

A major advance in the $1980$ s was the development of technology to synthesize short oligonucleotides. This work both facilitated DNA sequencing and led to the advent of the development of PCR. Recently, rapid advances have occurred in the technology to chemically synthesize DNA, and sequences up to $10$ kbare now readily produced. As this process becomes more economical, how will it affect the gene $\text{-}$ cloning approaches outlined in this chapter? In other words, what types of techniques does this new technology have potential to supplant, and what techniques will not be affected by it?