Laboratory Manual for Human Anatomy & Physiology Main Version
4th Edition
ISBN: 9781260159110
Author: Terry Martin
Publisher: Mcgraw-hill Higher Education (us)
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Textbook Question
Chapter 15, Problem 1.2A
The vertebral column extends from the skull to the __________.
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 15 Solutions
Laboratory Manual for Human Anatomy & Physiology Main Version
Ch. 15 - The most superior bone of the vertebral column is...Ch. 15 - The vertebral column possesses four curvatures....Ch. 15 - Humans have ___________ pairs of true ribs. two...Ch. 15 - The _________ ribs do not have costal cartilage...Ch. 15 - Humans possess ____________ cervical vertebrae....Ch. 15 - The superior end of the sacrum articulates with...Ch. 15 - The anterior (sternal) end of a rib articulates...Ch. 15 - All cervical, thoracic, and lumbar vertebrae...Ch. 15 - A feature of the second cervical vertebra is the...Ch. 15 - Note the four curvatures of the vertebral column....
Ch. 15 - The vertebral column encloses and protects the...Ch. 15 - The vertebral column extends from the skull to the...Ch. 15 - The seventh cervical vertebra is called the...Ch. 15 - The _____________________ of the vertebrae support...Ch. 15 - The __________ separate adjacent vertebrae, and...Ch. 15 - The intervertebral foramina provide passageways...Ch. 15 - Transverse foramina of _____________ vertebrae...Ch. 15 - The first vertebra also is called the...Ch. 15 - When the head is moved from side to side, the...Ch. 15 - The __________ vertebrae have the largest and...Ch. 15 - The typical number ofvertebrae that fuse in the...Ch. 15 - FIGURE 15.8 Label the bones and features of a...Ch. 15 - FIGURE 15.9 Identity the bones and features...Ch. 15 - An abnormal lateral curvature of the spine is...Ch. 15 - The manubrium, body, and xiphoid process form a...Ch. 15 - The last two pairs of fibs that have no...Ch. 15 - There are _____________ pairs of true ribs.Ch. 15 - Costal are composed of __________ tissue.Ch. 15 - The manubriunarticulates with _________ on its...Ch. 15 - List three general functions ofthe thoracic cage.Ch. 15 - The sternal angle indicates the location of the...Ch. 15 - FIGURE 15.11 Label the bones and features of the...
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