Microbiology: An Evolving Science (Fourth Edition)
Microbiology: An Evolving Science (Fourth Edition)
4th Edition
ISBN: 9780393615098
Author: John W. Foster, Joan L. Slonczewski
Publisher: W. W. Norton & Company
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Chapter 14.2, Problem 2TQ
Summary Introduction

To review:

The simple experiment providing evidence that a proton pump in the bacterial cell membrane drives the efflux of antibiotics such as tetracycline.

Introduction:

A proton gradient is created across the membrane by an essential membrane protein. This pump is known as the proton pump. These proton pumps efflux out hydrogen ions from low concentration medium to high concentration medium. Proton pump inhibits acid secretion and decreases the chances of ulcers in the stomach. Proton pump inhibitors also prevent the negative effect of the antibiotic on the cell membrane of the bacteria.

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