Concept explainers
(a) Interpretation:
The action of the itaconate on the substrate should be identified.
Concept introduction:
Aerobic glycolysis is the reaction of breakdown of glycogen to glucose in presence of oxygen whereas oxidative phosphorylation is the process in which cell produces energy in form of ATP for which enzyme is required. Itaconate is a metabolite used against microorganisms and it is synthesised in immune system of mammals. OCR is the oxygen consumption rate by the substrate in presence of itaconate. This itaconate become more in presence of oxygen.
(b) Interpretation:
Type of inhition of itaconate should be identified.
Concept introduction:
Competetive inhibition is the inhibition of the enzyme to attack on active site of substrate so that is cannot get attach in active site whereas, reversible inhibition is the inhibition through which inhibition the shape and structure of enzyme not changes. In irreversible inhibition the shape and structure of enzyme changes after getting inhibited.
(c) Interpretation:
Source of itaconate should be identified.
Concept introduction:
Aerobic glycolysis is the reaction of breakdown of glycogen to glucose in presence of oxygen whereas oxidative phosphorylation is the process in which cell produces energy in form of ATP for which enzyme is required. Itaconate is a metabolite used against microorganisms and it is synthesised in immune system of mammals. OCR is the oxygen consumption rate by the substrate in presence of itaconate. This itaconate become more in presence of oxygen.
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Biochemistry: Concepts and Connections (2nd Edition)
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