(a) To propose: The strong inhibitory property of the peptide pepstatin Introduction: Aspartic proteases include the protease enzymes which uses two very active aspartic acid complexes for the cleavage reaction of the peptide substrates. Pepstatin is a naturally present in the cell which has hexa-peptide structure with amino acid Statine and thus generally inhibits aspartyl proteases.

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Answer 1

Question

Chapter 14, Problem 3P

Interpretation Introduction

(a)

To propose:

The strong inhibitory property of the peptide pepstatin

Introduction:

Aspartic proteases include the protease enzymes which uses two very active aspartic acid complexes for the cleavage reaction of the peptide substrates. Pepstatin is a naturally present in the cell which has hexa-peptide structure with amino acid Statine and thus generally inhibits aspartyl proteases.

Interpretation Introduction

(b)

To explain:

Whether the pepstatin exhibit inhibits the HIV-1 protease or not.

Introduction:

Aspartic proteases include the protease enzymes which uses two very active aspartic acid complexes for the cleavage reaction of the peptide substrates. Pepstatin is a naturally present in the cell which has hexa-peptide structure with amino acid Statine and thus generally inhibits aspartyl proteases.

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Answer 2

Question

Chapter 14, Problem 3P

Interpretation Introduction

(a)

To propose:

The strong inhibitory property of the peptide pepstatin

Introduction:

Aspartic proteases include the protease enzymes which uses two very active aspartic acid complexes for the cleavage reaction of the peptide substrates. Pepstatin is a naturally present in the cell which has hexa-peptide structure with amino acid Statine and thus generally inhibits aspartyl proteases.

Interpretation Introduction

(b)

To explain:

Whether the pepstatin exhibit inhibits the HIV-1 protease or not.

Introduction:

Aspartic proteases include the protease enzymes which uses two very active aspartic acid complexes for the cleavage reaction of the peptide substrates. Pepstatin is a naturally present in the cell which has hexa-peptide structure with amino acid Statine and thus generally inhibits aspartyl proteases.

Expert Solution & Answer

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Answer 3

Question

Chapter 14, Problem 3P

Interpretation Introduction

(a)

To propose:

The strong inhibitory property of the peptide pepstatin

Introduction:

Aspartic proteases include the protease enzymes which uses two very active aspartic acid complexes for the cleavage reaction of the peptide substrates. Pepstatin is a naturally present in the cell which has hexa-peptide structure with amino acid Statine and thus generally inhibits aspartyl proteases.

Interpretation Introduction

(b)

To explain:

Whether the pepstatin exhibit inhibits the HIV-1 protease or not.

Introduction:

Aspartic proteases include the protease enzymes which uses two very active aspartic acid complexes for the cleavage reaction of the peptide substrates. Pepstatin is a naturally present in the cell which has hexa-peptide structure with amino acid Statine and thus generally inhibits aspartyl proteases.

Expert Solution & Answer

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Answer 4

Question

Chapter 14, Problem 3P

Interpretation Introduction

(a)

To propose:

The strong inhibitory property of the peptide pepstatin

Introduction:

Aspartic proteases include the protease enzymes which uses two very active aspartic acid complexes for the cleavage reaction of the peptide substrates. Pepstatin is a naturally present in the cell which has hexa-peptide structure with amino acid Statine and thus generally inhibits aspartyl proteases.

Interpretation Introduction

(b)

To explain:

Whether the pepstatin exhibit inhibits the HIV-1 protease or not.

Introduction:

Aspartic proteases include the protease enzymes which uses two very active aspartic acid complexes for the cleavage reaction of the peptide substrates. Pepstatin is a naturally present in the cell which has hexa-peptide structure with amino acid Statine and thus generally inhibits aspartyl proteases.

Expert Solution & Answer

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Answer 5

Chapter 14, Problem 3P

Interpretation Introduction

(a)

To propose:

The strong inhibitory property of the peptide pepstatin

Introduction:

Aspartic proteases include the protease enzymes which uses two very active aspartic acid complexes for the cleavage reaction of the peptide substrates. Pepstatin is a naturally present in the cell which has hexa-peptide structure with amino acid Statine and thus generally inhibits aspartyl proteases.

Interpretation Introduction

(b)

To explain:

Whether the pepstatin exhibit inhibits the HIV-1 protease or not.

Introduction:

Aspartic proteases include the protease enzymes which uses two very active aspartic acid complexes for the cleavage reaction of the peptide substrates. Pepstatin is a naturally present in the cell which has hexa-peptide structure with amino acid Statine and thus generally inhibits aspartyl proteases.

Answer 6

Chapter 14, Problem 3P

Interpretation Introduction

(a)

To propose:

The strong inhibitory property of the peptide pepstatin

Introduction:

Aspartic proteases include the protease enzymes which uses two very active aspartic acid complexes for the cleavage reaction of the peptide substrates. Pepstatin is a naturally present in the cell which has hexa-peptide structure with amino acid Statine and thus generally inhibits aspartyl proteases.

Answer 7

Chapter 14, Problem 3P

Interpretation Introduction

(a)

To propose:

The strong inhibitory property of the peptide pepstatin

Introduction:

Aspartic proteases include the protease enzymes which uses two very active aspartic acid complexes for the cleavage reaction of the peptide substrates. Pepstatin is a naturally present in the cell which has hexa-peptide structure with amino acid Statine and thus generally inhibits aspartyl proteases.

Answer 8

Interpretation Introduction

(b)

To explain:

Whether the pepstatin exhibit inhibits the HIV-1 protease or not.

Introduction:

Aspartic proteases include the protease enzymes which uses two very active aspartic acid complexes for the cleavage reaction of the peptide substrates. Pepstatin is a naturally present in the cell which has hexa-peptide structure with amino acid Statine and thus generally inhibits aspartyl proteases.

Answer 9

Interpretation Introduction

(b)

To explain:

Whether the pepstatin exhibit inhibits the HIV-1 protease or not.

Introduction:

Aspartic proteases include the protease enzymes which uses two very active aspartic acid complexes for the cleavage reaction of the peptide substrates. Pepstatin is a naturally present in the cell which has hexa-peptide structure with amino acid Statine and thus generally inhibits aspartyl proteases.

Answer 10

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Answer 11

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Answer 12

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Answer 13

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Solution Summary: The author explains that the strong inhibitory property of pepstatin is due to the transformation of the central amino acid to a transition state.

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