Microbiology: A Systems Approach
5th Edition
ISBN: 9781259706615
Author: Marjorie Kelly Cowan Professor
Publisher: McGraw-Hill Education
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Chapter 13.2, Problem 11AYP
Summary Introduction
To explain:
The epigenetic change and the way in which it influences virulence.
Concept introduction:
Change which is brought out in damaged host cells is known as epigenetic change. These changes appear in the host cell at the time of attack. These epigenetic changes are related to the change in the DNA structure or mechanism of the cell.
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Students have asked these similar questions
19. On the diagram below
a. Label the three pictures as: DNA; polypeptide; or RNA.
b. Label the arrows as: translation or transcription/RNA processing.
c. Add the following details to the diagram.
Promoter region
TATA box
Transcription start site
Transcription terminator
Intron (A,B,C,D)
Exons (1,2,3,4,5)
Splice sites
5' cap
5' UTR (untranslated region)
3' poly A tail
3' UTR (untranslated region)
Translational start (AUG)
Translational stop (UGA, UAG, or UAA)
N and C ends of polypeptide
0000
Match the letter labels in the figure below to the terms. Some letter
labels are not used.
MNNNNNNIN
M
C
B
A
M
D
F
E
H
K
G
8
The diagram below illustrates a quorum sensing pathway from Staphylococcus aureus. Please answer the following questions.
1. Autoinduction is part of the quorum sensing system. Which promoter (P2 or P3) is critical for autoinduction?
2)This staphylococcus aureus grows on human wounds, causing severe infections. You would like to start a clinical trial to treat these wound infections. Please describe:
a) What molecule do you recommend for the trial. Why?
b) Your trial requires that Staphylococcus aureus be isolated from the wound and submitted to genome sequencing before admittance. Why? What are you testing for?
3) If a mutation arises where the Promoter P3 is constitutively active, how would that influence sensitivity to AIP? Please explain your rationale.
4) This pathway is sensitive to bacterial cell density. Describe two separate mutation that would render the pathway active independent of cell density. Briefly explain your rationale.
Mutation 1
Mutation 2
Chapter 13 Solutions
Microbiology: A Systems Approach
Ch. 13.1 - Prob. 1AYPCh. 13.1 - Identify the sites where normal biota is found in...Ch. 13.1 - Discuss how the Human Microbiome Project has...Ch. 13.2 - Prob. 4AYPCh. 13.2 - Differentiate between a microbes pathogenicity and...Ch. 13.2 - List the steps a microbe has to take to get to the...Ch. 13.2 - Prob. 7AYPCh. 13.2 - Prob. 8AYPCh. 13.2 - Prob. 9AYPCh. 13.2 - Prob. 10AYP
Ch. 13.2 - Prob. 11AYPCh. 13.2 - Draw and label a curve representing the course of...Ch. 13.2 - Prob. 13AYPCh. 13.2 - List six different modes of horizontal...Ch. 13.2 - Define healthcare-associated infection, listing...Ch. 13.2 - List Kochs postulates, and explain alternative...Ch. 13.3 - Summarize the goals of epidemiology and the role...Ch. 13.3 - Identify why some diseases are notifiable, and...Ch. 13.3 - Prob. 19AYPCh. 13.3 - Discuss the three major types of epidemics, and...Ch. 13.3 - Prob. 21AYPCh. 13 - Prob. 1MCQCh. 13 - Prob. 2MCQCh. 13 - Prob. 3MCQCh. 13 - Prob. 4MCQCh. 13 - Prob. 5MCQCh. 13 - Prob. 6MCQCh. 13 - Prob. 7MCQCh. 13 - Prob. 8MCQCh. 13 - A positive antibody test for HIV would be a...Ch. 13 - Prob. 10MCQCh. 13 - Prob. 11TFCh. 13 - Prob. 12TFCh. 13 - Prob. 13TFCh. 13 - Prob. 14TFCh. 13 - Prob. 15TFCh. 13 - Based upon data from the Human Microbiome Project...Ch. 13 - Prob. 2CTQCh. 13 - Prob. 3CTQCh. 13 - Prob. 4CTQCh. 13 - Prob. 5CTQCh. 13 - Prob. 1VCCh. 13 - Appendix D provides guidance for working with...
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