Laboratory Manual for Human Anatomy
5th Edition
ISBN: 9781259683831
Author: Eric Wise, Kenneth S. Saladin Dr.
Publisher: McGraw-Hill Education
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Textbook Question
Chapter 13, Problem 2TYC
How would nervous system function be affected if both the presynaptic and postsynaptic neurons at every had both synaptic vesicles and neurotransmitter receptors?
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 13 Solutions
Laboratory Manual for Human Anatomy
Ch. 13.1 - Define receptor and effector. Give two examples of...Ch. 13.1 - Prob. 2BYGOCh. 13.1 - Prob. 3BYGOCh. 13.2 - What basic physiological properties do a nerve...Ch. 13.2 - Prob. 2AWYKCh. 13.2 - Prob. 4BYGOCh. 13.2 - Prob. 5BYGOCh. 13.2 - Prob. 6BYGOCh. 13.2 - Prob. 7BYGOCh. 13.3 - From memory, make your own table of the six kinds...
Ch. 13.3 - Prob. 9BYGOCh. 13.3 - Compare the signal conduction speed in myelinated...Ch. 13.3 - Prob. 11BYGOCh. 13.4 - Of all the methods of membrane transport described...Ch. 13.4 - Prob. 12BYGOCh. 13.4 - Prob. 13BYGOCh. 13.4 - Prob. 14BYGOCh. 13.4 - Prob. 15BYGOCh. 13.4 - Prob. 16BYGOCh. 13.4 - Prob. 17BYGOCh. 13.5 - Prob. 18BYGOCh. 13.5 - Prob. 19BYGOCh. 13.5 - What single adult structure arises from all five...Ch. 13.5 - Prob. 21BYGOCh. 13 - The body’s two principal mechanisms of internal...Ch. 13 - Prob. 13.1.2AYLOCh. 13 - The two divisions of the PNS and the two...Ch. 13 - Prob. 13.1.4AYLOCh. 13 - Prob. 13.2.1AYLOCh. 13 - Prob. 13.2.2AYLOCh. 13 - Prob. 13.2.3AYLOCh. 13 - Prob. 13.2.4AYLOCh. 13 - Prob. 13.3.1AYLOCh. 13 - Prob. 13.3.2AYLOCh. 13 - Prob. 13.3.3AYLOCh. 13 - The structure, composition, and function of the...Ch. 13 - The relationship of Schwann cells to the myelin,...Ch. 13 - Prob. 13.3.6AYLOCh. 13 - Prob. 13.3.7AYLOCh. 13 - How the velocity of a nerve singnal varies with a...Ch. 13 - Prob. 13.3.9AYLOCh. 13 - Prob. 13.4.1AYLOCh. 13 - Prob. 13.4.2AYLOCh. 13 - Three types of synapses defined by where the...Ch. 13 - Prob. 13.4.4AYLOCh. 13 - Prob. 13.4.5AYLOCh. 13 - Prob. 13.4.6AYLOCh. 13 - Prob. 13.4.7AYLOCh. 13 - Prob. 13.4.8AYLOCh. 13 - Prob. 13.4.9AYLOCh. 13 - Prob. 13.4.10AYLOCh. 13 - The four principal types of neural circuits...Ch. 13 - Prob. 13.5.1AYLOCh. 13 - Prob. 13.5.2AYLOCh. 13 - Prob. 13.5.3AYLOCh. 13 - Prob. 13.5.4AYLOCh. 13 - Prob. 13.5.5AYLOCh. 13 - Prob. 13.5.6AYLOCh. 13 - The integrative functions of the nervous system...Ch. 13 - Prob. 2TYRCh. 13 - Prob. 3TYRCh. 13 - Prob. 4TYRCh. 13 - Prob. 5TYRCh. 13 - Prob. 6TYRCh. 13 - Another name for the axon of a neuron is nerve...Ch. 13 - Prob. 8TYRCh. 13 - Prob. 9TYRCh. 13 - Which of the following appears earlier than all...Ch. 13 - Prob. 11TYRCh. 13 - Prob. 12TYRCh. 13 - Prob. 13TYRCh. 13 - Neurons receive incoming signals by way of...Ch. 13 - Prob. 15TYRCh. 13 - Prob. 16TYRCh. 13 - Prob. 17TYRCh. 13 - Prob. 18TYRCh. 13 - Prob. 19TYRCh. 13 - Prob. 20TYRCh. 13 - Prob. 1BYMVCh. 13 - Prob. 2BYMVCh. 13 - State a meaning of each word element and give a...Ch. 13 - Prob. 4BYMVCh. 13 - Prob. 5BYMVCh. 13 - Prob. 6BYMVCh. 13 - Prob. 7BYMVCh. 13 - Prob. 8BYMVCh. 13 - Prob. 9BYMVCh. 13 - Prob. 10BYMVCh. 13 - Prob. 1TOFCh. 13 - Prob. 2TOFCh. 13 - Prob. 3TOFCh. 13 - Prob. 4TOFCh. 13 - Prob. 5TOFCh. 13 - Briefly explain why each of the following...Ch. 13 - Determine which five of the following statements...Ch. 13 - Briefly explain why each of the following...Ch. 13 - Prob. 9TOFCh. 13 - Prob. 10TOFCh. 13 - Suppose some hypothetical disease prevented the...Ch. 13 - How would nervous system function be affected if...Ch. 13 - What unusual characteristic of neurons can be...Ch. 13 - Prob. 4TYCCh. 13 - Prob. 5TYC
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