HUMAN ANATOMY PKG >CUSTOM<
8th Edition
ISBN: 9781323572528
Author: Marieb
Publisher: Pearson Custom Publishing
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Chapter 13, Problem 20CYU
Name the dura mater extension that lies in the longitudinal fissure.
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 13 Solutions
HUMAN ANATOMY PKG >CUSTOM<
Ch. 13 - Prob. 1CYUCh. 13 - Prob. 2CYUCh. 13 - Name the structure that connects the third...Ch. 13 - Prob. 4CYUCh. 13 - In which part of the brain stem are each of the...Ch. 13 - What are the corpora quadrigemina?Ch. 13 - Name the structure that connects the two...Ch. 13 - What type of sensory information does the...Ch. 13 - Name the three white fiber tracts that connect the...Ch. 13 - Prob. 10CYU
Ch. 13 - What part of the diencephalon functions as the...Ch. 13 - What is the difference in function between a...Ch. 13 - Which functional area of the cerebral cortex plans...Ch. 13 - Define contralateral projection.Ch. 13 - What deficits may result from injury to the...Ch. 13 - Prob. 16CYUCh. 13 - Where is the caudate nucleus located in reference...Ch. 13 - From where do the reticular nuclei receive input?...Ch. 13 - What emotional response does the amygdaloid body...Ch. 13 - Name the dura mater extension that lies in the...Ch. 13 - Where is cerebrospinal fluid produced? How is it...Ch. 13 - What neural structures pass through the vertebraI...Ch. 13 - Which portion of the spinal cord, gray matter or...Ch. 13 - Prob. 24CYUCh. 13 - Which two meninges border the space that is filled...Ch. 13 - Which sensory pathway carries discriminative touch...Ch. 13 - Of the sensory pathways described, which pass...Ch. 13 - Which descending fiber tract originates from the...Ch. 13 - Which of the pathways illustrated here (ascending...Ch. 13 - Individuals who have suffered a stroke generally...Ch. 13 - Prob. 31CYUCh. 13 - Choose the correct brain structure from the key...Ch. 13 - A patient suffered a cerebral hemorrhage that...Ch. 13 - Destruction of the ventral horn cells of the...Ch. 13 - For each of the following brain structures, write...Ch. 13 - Which of the following areas is most likely to...Ch. 13 - Prob. 6RQCh. 13 - (a) Make a rough sketch of a lateral view of the...Ch. 13 - Prob. 8RQCh. 13 - Prob. 9RQCh. 13 - Prob. 10RQCh. 13 - (a) Describe the location of the reticular...Ch. 13 - Prob. 12RQCh. 13 - (a) What are the superior and inferior boundaries...Ch. 13 - Prob. 14RQCh. 13 - (a) In the spinothalamic pathway, where are the...Ch. 13 - Prob. 16RQCh. 13 - Prob. 17RQCh. 13 - A brain surgeon removed a piece of a woman's skull...Ch. 13 - Prob. 19RQCh. 13 - Prob. 20RQCh. 13 - Prob. 21RQCh. 13 - Describe the location and function of the ventral...Ch. 13 - Kimberly learned that the basic design of the CNS...Ch. 13 - When Ralph had brain surgery to remove a small...Ch. 13 - When their second child was born, Kiko and Taka...Ch. 13 - Cesar, a brilliant computer analyst, was hit on...Ch. 13 - One war veteran was tetraplegic, and another was...Ch. 13 - Every time Spike went to a boxing match, he...Ch. 13 - A spinal cord injury at C2 results not only in...Ch. 13 - What parts of the brain are still developing...Ch. 13 - Strokes, tumors, or wounds can destroy limited...
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