Anatomy & Physiology: The Unity of Form and Function
8th Edition
ISBN: 9781259277726
Author: Kenneth S. Saladin Dr.
Publisher: McGraw-Hill Education
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Chapter 12.5, Problem 19BYGO
Summary Introduction
Introduction:
Neurotransmitters are organic molecules synthesized by a nerve cell; it is released when a nerve signal reaches the terminal of the axon or nerve fiber varicosity. The neurotransmitters have specialized effect on receiving cell’s physiology. Neurotransmitters are released by exocytosis that binds to specific receptors of the receiving cell. Some of the neurotransmitters are inhibitory, some are excitatory, and for others, the end product depends on the type of receptor the postsynaptic cell has.
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What type of synaptic potential (if any; be sure to indicate if any modification is occurring as well) would occur if:
a.) An MAO inhibitor type of antidepressant is functioning at an active dopaminergic synapse that increases the rate of sodium flowing into the cell.
b.) Prozac is present at an active serotonin synapse where receptor activation increases the flow of potassium out of the cell.
The following diagram represents a typical serotonergic synapse. Where, specifically, do
antidepressants work (e.g. SSRI)?
Neurotransmitter
Neurotransmitter
transporter
Аxon
Synaptic
vesicle
terminal
Voltage-
gated Ca?+
channel
Synaptic
cleft
Receptor
Postsynaptic
density
Dendrite
Neurotransmitter
Synaptic Vesicle
Neurotransmitter transporter (aka Reuptake transporter)
Receptor
O All of the above
Nervous system functions that directly employ acetylcholine neurotransmitters are referred to as cholinergic. Drugs that might be therapeutic in treating the symptoms of dopamine loss in Parkinson’s disease could include
multiple choice 1
dopaminergic agonists and cholinergic antagonists.
dopaminergic antagonists and cholinergic antagonists.
dopaminergic antagonists and cholinergic agonists.
dopaminergic agonists and cholinergic agonists.
2. From the information provided, drugs used to treat Parkinson’s disease symptoms will act at which location?
multiple choice 2
The globus pallidus
The substantia nigra
The striatum
3. Which of the following might be therapeutic in the treatment of Parkinson’s disease symptoms?
multiple choice 3
all of these choices listed may be therapeutic
increasing dopamine receptor responsiveness
monoamine oxidase inhibition
increasing dopamine release
decreasing dopamine…
Chapter 12 Solutions
Anatomy & Physiology: The Unity of Form and Function
Ch. 12.1 - What is a receptor? Give two examples of...Ch. 12.1 - Distinguish between the central and peripheral...Ch. 12.1 - Prob. 3BYGOCh. 12.1 - What the nervous and endocrine systems have in...Ch. 12.1 - Three fundamental functions of the nervous system;...Ch. 12.1 - Differences between the central nervous system...Ch. 12.1 - The autonomic nervous system and its two divisionsCh. 12.2 - Sketch a multipolar neuron and label its...Ch. 12.2 - Explain the differences between a sensory neuron,...Ch. 12.2 - Prob. 6BYGO
Ch. 12.2 - Prob. 7BYGOCh. 12.2 - Three fundamental physiological properties of...Ch. 12.2 - Prob. 2AYLOCh. 12.2 - Prob. 3AYLOCh. 12.2 - Prob. 4AYLOCh. 12.2 - Ways in winch neurons transport substances between...Ch. 12.3 - Prob. 8BYGOCh. 12.3 - Prob. 9BYGOCh. 12.3 - Prob. 10BYGOCh. 12.3 - Six kinds of neuroglia; the structure and...Ch. 12.3 - Prob. 2AYLOCh. 12.3 - Prob. 3AYLOCh. 12.3 - The regeneration of a damaged nerve fiber; the...Ch. 12.4 - Prob. 11BYGOCh. 12.4 - Prob. 12BYGOCh. 12.4 - Prob. 13BYGOCh. 12.4 - Prob. 14BYGOCh. 12.4 - Prob. 15BYGOCh. 12.4 - Prob. 16BYGOCh. 12.4 - Prob. 17BYGOCh. 12.4 - Prob. 1AYLOCh. 12.4 - What an electrical current is, and how sodium ions...Ch. 12.4 - How stimulation of a neuron generates a local...Ch. 12.4 - Prob. 4AYLOCh. 12.4 - Prob. 5AYLOCh. 12.4 - Prob. 6AYLOCh. 12.4 - Prob. 7AYLOCh. 12.4 - How one action potential triggers another; how the...Ch. 12.4 - Saltatory conduction in a myelinated nerve fiber,...Ch. 12.5 - Prob. 18BYGOCh. 12.5 - Prob. 19BYGOCh. 12.5 - Prob. 20BYGOCh. 12.5 - Prob. 21BYGOCh. 12.5 - Prob. 1AYLOCh. 12.5 - Prob. 2AYLOCh. 12.5 - Prob. 3AYLOCh. 12.5 - Prob. 4AYLOCh. 12.5 - Excitatory synapses; how acetylcholine and...Ch. 12.5 - Prob. 6AYLOCh. 12.5 - Prob. 7AYLOCh. 12.5 - Prob. 8AYLOCh. 12.5 - Prob. 9AYLOCh. 12.6 - Prob. 22BYGOCh. 12.6 - Prob. 23BYGOCh. 12.6 - Prob. 24BYGOCh. 12.6 - Contrast serial and parallel processing and...Ch. 12.6 - Prob. 26BYGOCh. 12.6 - Explain how long-term potentiation and long-term...Ch. 12.6 - Prob. 1AYLOCh. 12.6 - Prob. 2AYLOCh. 12.6 - Prob. 3AYLOCh. 12.6 - How a postsynaptic neurons decision to fire...Ch. 12.6 - Prob. 5AYLOCh. 12.6 - Mechanisms of presynaptic facilitation and...Ch. 12.6 - Prob. 7AYLOCh. 12.6 - Prob. 8AYLOCh. 12.6 - The meanings of neural pool and neural circuitCh. 12.6 - The difference between a neurons discharge zone...Ch. 12.6 - Diverging, converging, reverberating, and parallel...Ch. 12.6 - The difference between serial and parallel...Ch. 12.6 - The cellular basis of memory; what memory consists...Ch. 12.6 - Prob. 14AYLOCh. 12.6 - Prob. 15AYLOCh. 12 - The integrative functions of the nervous system...Ch. 12 - The highest density of voltage-gated ion channels...Ch. 12 - The soma of a mature neuron lacks a. a nucleus. b....Ch. 12 - The glial cells that fight infections in the CNS...Ch. 12 - Posttetanic potentiation of a synapse increases...Ch. 12 - An IPSP is_____of the postsynaptic neuron. a. a...Ch. 12 - Prob. 7TYRCh. 12 - Prob. 8TYRCh. 12 - Prob. 9TYRCh. 12 - Prob. 10TYRCh. 12 - Prob. 11TYRCh. 12 - Prob. 12TYRCh. 12 - Prob. 13TYRCh. 12 - Prob. 14TYRCh. 12 - Prob. 15TYRCh. 12 - A myelinated nerve fiber can produce action...Ch. 12 - Prob. 17TYRCh. 12 - Prob. 18TYRCh. 12 - Prob. 19TYRCh. 12 - Prob. 20TYRCh. 12 - Prob. 1BYMVCh. 12 - Prob. 2BYMVCh. 12 - Prob. 3BYMVCh. 12 - Prob. 4BYMVCh. 12 - Prob. 5BYMVCh. 12 - Prob. 6BYMVCh. 12 - Prob. 7BYMVCh. 12 - Prob. 8BYMVCh. 12 - Prob. 9BYMVCh. 12 - Prob. 10BYMVCh. 12 - Prob. 1WWTSCh. 12 - Prob. 2WWTSCh. 12 - Prob. 3WWTSCh. 12 - Prob. 4WWTSCh. 12 - Excitatory postsynaptic potentials lower the...Ch. 12 - Prob. 6WWTSCh. 12 - Prob. 7WWTSCh. 12 - Myelinated nerve fibers conduct signals more...Ch. 12 - Prob. 9WWTSCh. 12 - Prob. 10WWTSCh. 12 - Schizophrenia is sometimes treated with drugs such...Ch. 12 - Hyperkalemia is an excess of potassium ill the...Ch. 12 - Suppose a poison were to slow down the Na+-K+...Ch. 12 - Prob. 4TYCCh. 12 - Prob. 5TYC
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- Assume presynaptic excitatory neuron A terminates on a postsynaptic cell near the axon hillock and presynaptic excitatory neuron B terminates on the same postsynaptic cell on a dendrite located on the side of the cell body opposite the axon hillock. Explain why rapid firing of presynaptic neuron A could bring the postsynaptic neuron to threshold through temporal summation, thus initiating an action potential, whereas firing of presynaptic neuron B at the same frequency and the same magnitude of EPSPs may not bring the postsynaptic neuron to threshold.arrow_forwardStudies have shown that individuals with attention deficit hyperactivity disorder (ADHD) may have lower than normal amounts of dopamine and norepinephrine excitatory neurotransmitters in their synapses. Methylphenidate is one of the drugs prescribed to individuals with ADHD. It prevents the reuptake of dopamine and norepinephrine neurotransmitters from the synapses, thereby keeping these neurotransmitters in the synapses longer. Which of the following rows correctly identify the effects of methylphenidate in individuals with ADHD? Select one: a. There is an increase in the permeability of the presynaptic neuron to potassium ions. b. There is a increase in the permeability of the postsynaptic neuron to potassium ions. c. There is an increase in the permeability of the presynaptic neuron to sodium ions. d. There is a increase in the permeability of the postsynaptic neuron to sodium ions.arrow_forwardStudies have shown that individuals with attention deficit hyperactivity disorder (ADHD) may have lower than normal amounts of dopamine and norepinephrine excitatory neurotransmitters in their synapses. Methylphenidate is one of the drugs prescribed to individuals with ADHD. It prevents the reuptake of dopamine and norepinephrine neurotransmitters from the synapses, thereby keeping these neurotransmitters in the synapses longer. Which of the following rows correctly identify the effects of methylphenidate in individuals with ADHD? Select one: a. There is an increase in the permeability of the presynaptic neuron to potassium ions. b. There is a increase in the permeability of the postsynaptic neuron to potassium ions. c. There is an increase in the permeability of the presynaptic neuron to sodium ions. d. There is a increase in the permeability of the postsynaptic neuron to sodium ions.arrow_forward
- Propose a mechanism for the conversion of (C) to (D). (Note: It is not acceptable to propose a primary carbocation as an intermediate.)arrow_forwardPropose reagents for the conversion of (B) to (C).arrow_forwardParkinson's Disease Parkinson's disease is neurodegenerative disorder that affects movement. Most people affected with Parkinson's disease demonstrate rigidity, slow movement, and shaking. The symptoms of Parkinson's disease occur when the cells that produce dopamine neurotransmitters die in the brain. Explain how the signal transmission at a synapse in an individual with Parkinson's disease is different than an unaffected individual. Describe the normal process of signal transmission at a synapse. Start with the arrival of an action potential at the axon terminal and include the name of the neurotransmitter that is affected by Parkinson's disease. Explain how the process is different in individuals affected with Parkinson's disease.arrow_forward
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- Identify two neural pathways in the brain that use dopamine as a neurotransmitter, andexplain their significance.arrow_forwardClassify the following neurotransmitters as excitatory or inhibitory: Acetylcholine Serotonin GABA Norepinephrine Glutamate Dopaminearrow_forwardthe bacterium clostridium tetani produce a toxin called tetanospasmin, the causative agent os the disease tetanus. the toxin prevents the release of inhibitory transmitters in the CNS and so blocks the resulting IPSPs they would normally generate. what are some of the functions of inhibitory synapses? considering this what symptoms would you expect from the disease tetanus, and why? ( hint: imagine trying to stand up if all of the muscles in your lower limb contracted at the same time.)arrow_forward
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