The products of the given reaction have to be found. Concept Introduction: Grignard reaction with ketone : Grignard regent reacts with ketone followed by acidic work up to form secondary or tertiary alcohol. General scheme:

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Answer 1

Question

Chapter 12, Problem 46P

(a)

Interpretation Introduction

Interpretation: The products of the given reaction have to be found.

Concept Introduction:

Grignard reaction with ketone:

Grignard regent reacts with ketone followed by acidic work up to form secondary or tertiary alcohol.

General scheme:

(b)

Interpretation Introduction

Interpretation: The products of the given reaction have to be found.

Concept Introduction:

Hemiketals:

Hemiaketals are compounds with the functional group C(OH)(OR). These compounds will be formed as intermediates in the formation of Ketals from ketones which is shown in the following general scheme:

General scheme:

(c)

Interpretation Introduction

Interpretation: The products of the given reaction have to be found.

Concept Introduction:

Major product in the reaction of α,β- unsaturated carbonyl compounds with weak bases:

α,β- Unsaturated carbonyl compounds on reaction with weak bases gives conjugate addition products as the major products as shown in the following general scheme:

General scheme:

It can be observed that the conjugate addition product has been formed by the addition of basic anion to the beta-carbon atom and that of hydrogen atom to the alpha-carbon carbon atom.

The examples for the weak bases are:

• HBr• CH3SH• CH3OH• NH3

(d)

Interpretation Introduction

Interpretation: The products of the given reaction have to be found.

Concept Introduction:

Major product in the reaction of α,β- unsaturated carbonyl compounds with weak bases:

α,β- Unsaturated carbonyl compounds on reaction with weak bases gives conjugate addition products as the major products as shown in the following general scheme:

General scheme:

It can be observed that the conjugate addition product has been formed by the addition of basic anion to the beta-carbon atom and that of hydrogen atom to the alpha-carbon carbon atom.

The examples for the weak bases are:

• HBr• CH3SH• CH3OH• NH3

Major product in the reaction of α,β- unsaturated carbonyl compounds with strong bases:

α,β- Unsaturated carbonyl compounds on reaction with strong bases gives direct addition products as the major products as shown in the following general scheme:

General scheme:

It can be observed that the direct addition product has been formed from the direct reaction of the strong base with the carbonyl functional group of the α,β- unsaturated carbonyl compounds.

The examples for the strong bases are:

• −CH3Mg2+Br−⇒ Gignard reagent• NaBH4⇒ H- hydride donor

Aminolysis reaction:

The aminolysis reaction is just like hydrolysis in which one component gets converted into two components using a molecule of amine like using a molecule of water in hydrolysis.

In the aminolysis of ester, one ester component reacts with a molecule of amine and will be converted into two components such as an amide and an alcohol which has been shown in the following general scheme:

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You have now performed a liquid-liquid extraction protocol in Experiment 4. In doing so, you manipulated and exploited the acid-base chemistry of one or more of the compounds in your mixture to facilitate their separation into different phases. The key to understanding how liquid- liquid extractions work is by knowing which layer a compound is in, and in what protonation state. The following liquid-liquid extraction is different from the one you performed in Experiment 4, but it uses the same type of logic. Your task is to show how to separate apart Compound A and Compound B. . Complete the following flowchart of a liquid-liquid extraction. Handwritten work is encouraged. • Draw by hand (neatly) only the appropriate organic compound(s) in the boxes. . Specify the reagent(s)/chemicals (name is fine) and concentration as required in Boxes 4 and 5. • Box 7a requires the solvent (name is fine). • Box 7b requires one inorganic compound. • You can neatly complete this assignment by hand and…

b) Elucidate compound D w) mt at 170 nd shows c-1 stretch at 550cm;' The compound has the ff electronic transitions: 0%o* and no a* 1H NMR Spectrum (CDCl3, 400 MHz) 3.5 3.0 2.5 2.0 1.5 1.0 0.5 ppm 13C{H} NMR Spectrum (CDCl3, 100 MHz) Solvent 80 70 60 50 40 30 20 10 0 ppm ppm ¹H-13C me-HSQC Spectrum ppm (CDCl3, 400 MHz) 5 ¹H-¹H COSY Spectrum (CDCl3, 400 MHz) 0.5 10 3.5 3.0 2.5 2.0 1.5 1.0 10 15 20 20 25 30 30 -35 -1.0 1.5 -2.0 -2.5 3.0 -3.5 0.5 ppm 3.5 3.0 2.5 2.0 1.5 1.0 0.5 ppm

Show work with explanation. don't give Ai generated solution

Answer 2

Question

Chapter 12, Problem 46P

(a)

Interpretation Introduction

Interpretation: The products of the given reaction have to be found.

Concept Introduction:

Grignard reaction with ketone:

Grignard regent reacts with ketone followed by acidic work up to form secondary or tertiary alcohol.

General scheme:

(b)

Interpretation Introduction

Interpretation: The products of the given reaction have to be found.

Concept Introduction:

Hemiketals:

Hemiaketals are compounds with the functional group C(OH)(OR). These compounds will be formed as intermediates in the formation of Ketals from ketones which is shown in the following general scheme:

General scheme:

(c)

Interpretation Introduction

Interpretation: The products of the given reaction have to be found.

Concept Introduction:

Major product in the reaction of α,β- unsaturated carbonyl compounds with weak bases:

α,β- Unsaturated carbonyl compounds on reaction with weak bases gives conjugate addition products as the major products as shown in the following general scheme:

General scheme:

It can be observed that the conjugate addition product has been formed by the addition of basic anion to the beta-carbon atom and that of hydrogen atom to the alpha-carbon carbon atom.

The examples for the weak bases are:

• HBr• CH3SH• CH3OH• NH3

(d)

Interpretation Introduction

Interpretation: The products of the given reaction have to be found.

Concept Introduction:

Major product in the reaction of α,β- unsaturated carbonyl compounds with weak bases:

α,β- Unsaturated carbonyl compounds on reaction with weak bases gives conjugate addition products as the major products as shown in the following general scheme:

General scheme:

It can be observed that the conjugate addition product has been formed by the addition of basic anion to the beta-carbon atom and that of hydrogen atom to the alpha-carbon carbon atom.

The examples for the weak bases are:

• HBr• CH3SH• CH3OH• NH3

Major product in the reaction of α,β- unsaturated carbonyl compounds with strong bases:

α,β- Unsaturated carbonyl compounds on reaction with strong bases gives direct addition products as the major products as shown in the following general scheme:

General scheme:

It can be observed that the direct addition product has been formed from the direct reaction of the strong base with the carbonyl functional group of the α,β- unsaturated carbonyl compounds.

The examples for the strong bases are:

• −CH3Mg2+Br−⇒ Gignard reagent• NaBH4⇒ H- hydride donor

Aminolysis reaction:

The aminolysis reaction is just like hydrolysis in which one component gets converted into two components using a molecule of amine like using a molecule of water in hydrolysis.

In the aminolysis of ester, one ester component reacts with a molecule of amine and will be converted into two components such as an amide and an alcohol which has been shown in the following general scheme:

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Answer 3

Question

Chapter 12, Problem 46P

(a)

Interpretation Introduction

Interpretation: The products of the given reaction have to be found.

Concept Introduction:

Grignard reaction with ketone:

Grignard regent reacts with ketone followed by acidic work up to form secondary or tertiary alcohol.

General scheme:

(b)

Interpretation Introduction

Interpretation: The products of the given reaction have to be found.

Concept Introduction:

Hemiketals:

Hemiaketals are compounds with the functional group C(OH)(OR). These compounds will be formed as intermediates in the formation of Ketals from ketones which is shown in the following general scheme:

General scheme:

(c)

Interpretation Introduction

Interpretation: The products of the given reaction have to be found.

Concept Introduction:

Major product in the reaction of α,β- unsaturated carbonyl compounds with weak bases:

α,β- Unsaturated carbonyl compounds on reaction with weak bases gives conjugate addition products as the major products as shown in the following general scheme:

General scheme:

It can be observed that the conjugate addition product has been formed by the addition of basic anion to the beta-carbon atom and that of hydrogen atom to the alpha-carbon carbon atom.

The examples for the weak bases are:

• HBr• CH3SH• CH3OH• NH3

(d)

Interpretation Introduction

Interpretation: The products of the given reaction have to be found.

Concept Introduction:

Major product in the reaction of α,β- unsaturated carbonyl compounds with weak bases:

α,β- Unsaturated carbonyl compounds on reaction with weak bases gives conjugate addition products as the major products as shown in the following general scheme:

General scheme:

It can be observed that the conjugate addition product has been formed by the addition of basic anion to the beta-carbon atom and that of hydrogen atom to the alpha-carbon carbon atom.

The examples for the weak bases are:

• HBr• CH3SH• CH3OH• NH3

Major product in the reaction of α,β- unsaturated carbonyl compounds with strong bases:

α,β- Unsaturated carbonyl compounds on reaction with strong bases gives direct addition products as the major products as shown in the following general scheme:

General scheme:

It can be observed that the direct addition product has been formed from the direct reaction of the strong base with the carbonyl functional group of the α,β- unsaturated carbonyl compounds.

The examples for the strong bases are:

• −CH3Mg2+Br−⇒ Gignard reagent• NaBH4⇒ H- hydride donor

Aminolysis reaction:

The aminolysis reaction is just like hydrolysis in which one component gets converted into two components using a molecule of amine like using a molecule of water in hydrolysis.

In the aminolysis of ester, one ester component reacts with a molecule of amine and will be converted into two components such as an amide and an alcohol which has been shown in the following general scheme:

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Answer 4

Question

Chapter 12, Problem 46P

(a)

Interpretation Introduction

Interpretation: The products of the given reaction have to be found.

Concept Introduction:

Grignard reaction with ketone:

Grignard regent reacts with ketone followed by acidic work up to form secondary or tertiary alcohol.

General scheme:

(b)

Interpretation Introduction

Interpretation: The products of the given reaction have to be found.

Concept Introduction:

Hemiketals:

Hemiaketals are compounds with the functional group C(OH)(OR). These compounds will be formed as intermediates in the formation of Ketals from ketones which is shown in the following general scheme:

General scheme:

(c)

Interpretation Introduction

Interpretation: The products of the given reaction have to be found.

Concept Introduction:

Major product in the reaction of α,β- unsaturated carbonyl compounds with weak bases:

α,β- Unsaturated carbonyl compounds on reaction with weak bases gives conjugate addition products as the major products as shown in the following general scheme:

General scheme:

It can be observed that the conjugate addition product has been formed by the addition of basic anion to the beta-carbon atom and that of hydrogen atom to the alpha-carbon carbon atom.

The examples for the weak bases are:

• HBr• CH3SH• CH3OH• NH3

(d)

Interpretation Introduction

Interpretation: The products of the given reaction have to be found.

Concept Introduction:

Major product in the reaction of α,β- unsaturated carbonyl compounds with weak bases:

α,β- Unsaturated carbonyl compounds on reaction with weak bases gives conjugate addition products as the major products as shown in the following general scheme:

General scheme:

It can be observed that the conjugate addition product has been formed by the addition of basic anion to the beta-carbon atom and that of hydrogen atom to the alpha-carbon carbon atom.

The examples for the weak bases are:

• HBr• CH3SH• CH3OH• NH3

Major product in the reaction of α,β- unsaturated carbonyl compounds with strong bases:

α,β- Unsaturated carbonyl compounds on reaction with strong bases gives direct addition products as the major products as shown in the following general scheme:

General scheme:

It can be observed that the direct addition product has been formed from the direct reaction of the strong base with the carbonyl functional group of the α,β- unsaturated carbonyl compounds.

The examples for the strong bases are:

• −CH3Mg2+Br−⇒ Gignard reagent• NaBH4⇒ H- hydride donor

Aminolysis reaction:

The aminolysis reaction is just like hydrolysis in which one component gets converted into two components using a molecule of amine like using a molecule of water in hydrolysis.

In the aminolysis of ester, one ester component reacts with a molecule of amine and will be converted into two components such as an amide and an alcohol which has been shown in the following general scheme:

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Answer 5

Chapter 12, Problem 46P

(a)

Interpretation Introduction

Interpretation: The products of the given reaction have to be found.

Concept Introduction:

Grignard reaction with ketone:

Grignard regent reacts with ketone followed by acidic work up to form secondary or tertiary alcohol.

General scheme:

(b)

Interpretation Introduction

Interpretation: The products of the given reaction have to be found.

Concept Introduction:

Hemiketals:

Hemiaketals are compounds with the functional group C(OH)(OR). These compounds will be formed as intermediates in the formation of Ketals from ketones which is shown in the following general scheme:

General scheme:

(c)

Interpretation Introduction

Interpretation: The products of the given reaction have to be found.

Concept Introduction:

Major product in the reaction of α,β- unsaturated carbonyl compounds with weak bases:

α,β- Unsaturated carbonyl compounds on reaction with weak bases gives conjugate addition products as the major products as shown in the following general scheme:

General scheme:

It can be observed that the conjugate addition product has been formed by the addition of basic anion to the beta-carbon atom and that of hydrogen atom to the alpha-carbon carbon atom.

The examples for the weak bases are:

• HBr• CH3SH• CH3OH• NH3

(d)

Interpretation Introduction

Interpretation: The products of the given reaction have to be found.

Concept Introduction:

Major product in the reaction of α,β- unsaturated carbonyl compounds with weak bases:

α,β- Unsaturated carbonyl compounds on reaction with weak bases gives conjugate addition products as the major products as shown in the following general scheme:

General scheme:

It can be observed that the conjugate addition product has been formed by the addition of basic anion to the beta-carbon atom and that of hydrogen atom to the alpha-carbon carbon atom.

The examples for the weak bases are:

• HBr• CH3SH• CH3OH• NH3

Major product in the reaction of α,β- unsaturated carbonyl compounds with strong bases:

α,β- Unsaturated carbonyl compounds on reaction with strong bases gives direct addition products as the major products as shown in the following general scheme:

General scheme:

It can be observed that the direct addition product has been formed from the direct reaction of the strong base with the carbonyl functional group of the α,β- unsaturated carbonyl compounds.

The examples for the strong bases are:

• −CH3Mg2+Br−⇒ Gignard reagent• NaBH4⇒ H- hydride donor

Aminolysis reaction:

The aminolysis reaction is just like hydrolysis in which one component gets converted into two components using a molecule of amine like using a molecule of water in hydrolysis.

In the aminolysis of ester, one ester component reacts with a molecule of amine and will be converted into two components such as an amide and an alcohol which has been shown in the following general scheme:

Answer 6

Chapter 12, Problem 46P

(a)

Interpretation Introduction

Interpretation: The products of the given reaction have to be found.

Concept Introduction:

Grignard reaction with ketone:

Grignard regent reacts with ketone followed by acidic work up to form secondary or tertiary alcohol.

General scheme:

Answer 7

Chapter 12, Problem 46P

(a)

Interpretation Introduction

Interpretation: The products of the given reaction have to be found.

Concept Introduction:

Grignard reaction with ketone:

Grignard regent reacts with ketone followed by acidic work up to form secondary or tertiary alcohol.

General scheme:

Answer 8

(b)

Interpretation Introduction

Interpretation: The products of the given reaction have to be found.

Concept Introduction:

Hemiketals:

Hemiaketals are compounds with the functional group C(OH)(OR). These compounds will be formed as intermediates in the formation of Ketals from ketones which is shown in the following general scheme:

General scheme:

Answer 9

(b)

Interpretation Introduction

Interpretation: The products of the given reaction have to be found.

Concept Introduction:

Hemiketals:

Hemiaketals are compounds with the functional group C(OH)(OR). These compounds will be formed as intermediates in the formation of Ketals from ketones which is shown in the following general scheme:

General scheme:

Answer 10

(c)

Interpretation Introduction

Interpretation: The products of the given reaction have to be found.

Concept Introduction:

Major product in the reaction of α,β- unsaturated carbonyl compounds with weak bases:

α,β- Unsaturated carbonyl compounds on reaction with weak bases gives conjugate addition products as the major products as shown in the following general scheme:

General scheme:

It can be observed that the conjugate addition product has been formed by the addition of basic anion to the beta-carbon atom and that of hydrogen atom to the alpha-carbon carbon atom.

The examples for the weak bases are:

• HBr• CH3SH• CH3OH• NH3

Answer 11

(c)

Interpretation Introduction

Interpretation: The products of the given reaction have to be found.

Concept Introduction:

Major product in the reaction of α,β- unsaturated carbonyl compounds with weak bases:

α,β- Unsaturated carbonyl compounds on reaction with weak bases gives conjugate addition products as the major products as shown in the following general scheme:

General scheme:

It can be observed that the conjugate addition product has been formed by the addition of basic anion to the beta-carbon atom and that of hydrogen atom to the alpha-carbon carbon atom.

The examples for the weak bases are:

• HBr• CH3SH• CH3OH• NH3

Answer 12

(d)

Interpretation Introduction

Interpretation: The products of the given reaction have to be found.

Concept Introduction:

Major product in the reaction of α,β- unsaturated carbonyl compounds with weak bases:

α,β- Unsaturated carbonyl compounds on reaction with weak bases gives conjugate addition products as the major products as shown in the following general scheme:

General scheme:

It can be observed that the conjugate addition product has been formed by the addition of basic anion to the beta-carbon atom and that of hydrogen atom to the alpha-carbon carbon atom.

The examples for the weak bases are:

• HBr• CH3SH• CH3OH• NH3

Major product in the reaction of α,β- unsaturated carbonyl compounds with strong bases:

α,β- Unsaturated carbonyl compounds on reaction with strong bases gives direct addition products as the major products as shown in the following general scheme:

General scheme:

It can be observed that the direct addition product has been formed from the direct reaction of the strong base with the carbonyl functional group of the α,β- unsaturated carbonyl compounds.

The examples for the strong bases are:

• −CH3Mg2+Br−⇒ Gignard reagent• NaBH4⇒ H- hydride donor

Aminolysis reaction:

The aminolysis reaction is just like hydrolysis in which one component gets converted into two components using a molecule of amine like using a molecule of water in hydrolysis.

In the aminolysis of ester, one ester component reacts with a molecule of amine and will be converted into two components such as an amide and an alcohol which has been shown in the following general scheme:

Answer 13

(d)

Interpretation Introduction

Interpretation: The products of the given reaction have to be found.

Concept Introduction:

Major product in the reaction of α,β- unsaturated carbonyl compounds with weak bases:

α,β- Unsaturated carbonyl compounds on reaction with weak bases gives conjugate addition products as the major products as shown in the following general scheme:

General scheme:

It can be observed that the conjugate addition product has been formed by the addition of basic anion to the beta-carbon atom and that of hydrogen atom to the alpha-carbon carbon atom.

The examples for the weak bases are:

• HBr• CH3SH• CH3OH• NH3

Major product in the reaction of α,β- unsaturated carbonyl compounds with strong bases:

α,β- Unsaturated carbonyl compounds on reaction with strong bases gives direct addition products as the major products as shown in the following general scheme:

General scheme:

It can be observed that the direct addition product has been formed from the direct reaction of the strong base with the carbonyl functional group of the α,β- unsaturated carbonyl compounds.

The examples for the strong bases are:

• −CH3Mg2+Br−⇒ Gignard reagent• NaBH4⇒ H- hydride donor

Aminolysis reaction:

The aminolysis reaction is just like hydrolysis in which one component gets converted into two components using a molecule of amine like using a molecule of water in hydrolysis.

In the aminolysis of ester, one ester component reacts with a molecule of amine and will be converted into two components such as an amide and an alcohol which has been shown in the following general scheme:

Answer 14

Expert Solution & Answer

Answer 15

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Answer 16

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Answer 17

Ch. 12.1 - Prob. 1P Ch. 12.1 - Name the following compounds:Ch. 12.1 - Prob. 3P Ch. 12.1 - Prob. 4P Ch. 12.2 - Prob. 5P Ch. 12.4 - Draw the structure for each of the following: a....Ch. 12.4 - Prob. 7P Ch. 12.5 - What products are formed when the following...Ch. 12.5 - Prob. 9P Ch. 12.5 - Prob. 10P

The products of the given reaction have to be found. Concept Introduction: Grignard reaction with ketone : Grignard regent reacts with ketone followed by acidic work up to form secondary or tertiary alcohol. General scheme:

Solution Summary: The author describes Grignard reaction with ketone followed by acidic work up to form secondary or tertiary alcohol. Hemiketals are compounds with the functional group ,-

Interpretation: The products of the given reaction have to be found.

Concept Introduction:

Grignard reaction with ketone:

Grignard regent reacts with ketone followed by acidic work up to form secondary or tertiary alcohol.

General scheme:

Want to see the full answer?

Chapter 12 Solutions

The products of the given reaction have to be found. Concept Introduction: Grignard reaction with ketone : Grignard regent reacts with ketone followed by acidic work up to form secondary or tertiary alcohol. General scheme:

Solution Summary: The author describes Grignard reaction with ketone followed by acidic work up to form secondary or tertiary alcohol. Hemiketals are compounds with the functional group ,-

Interpretation: The products of the given reaction have to be found. Concept Introduction: Grignard reaction with ketone: Grignard regent reacts with ketone followed by acidic work up to form secondary or tertiary alcohol. General scheme:

Want to see the full answer?

Chapter 12 Solutions

Interpretation: The products of the given reaction have to be found.

Concept Introduction:

Grignard reaction with ketone:

Grignard regent reacts with ketone followed by acidic work up to form secondary or tertiary alcohol.

General scheme: