Biological Science (7th Edition)
Biological Science (7th Edition)
7th Edition
ISBN: 9780134678320
Author: Scott Freeman, Kim Quillin, Lizabeth Allison, Michael Black, Greg Podgorski, Emily Taylor, Jeff Carmichael
Publisher: PEARSON
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Chapter 12, Problem 11PIAT

The bark of the Pacific yew tree (Taxusbrevifolia) was the original source of one of the most effective drugs for treating tumors of the breast, lung, and other sites. Taxol, a chemical extracted from this bark, kills actively replicating cells by inhibiting the depolymerization of microtubules. Why are microtubules good targets for killing cancerous cells?

During what phases in the cell cycle would you expect there to be large changes in the polymerization or depolymerization of microtubules? Why are these changes necessary?

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