Campbell Biology in Focus (2nd Edition)
2nd Edition
ISBN: 9780321962751
Author: Lisa A. Urry, Michael L. Cain, Steven A. Wasserman, Peter V. Minorsky, Jane B. Reece
Publisher: PEARSON
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Textbook Question
Chapter 12, Problem 10TYU
SCIENTIFIC INQUIRY
DRAW IT Assume you are mapping genes A, B, C, and D in Drosophila. You know that these genes are linked on the same chromosome, and you determine the recombination frequencies between each pair of genes to be as follows: A and B, 8%; A and C, 28%; A and D, 25%; 8 and C, 20%, B and D, 33%.
- a. Describe how you determined the recombination frequency for each pair of genes.
- b. Draw a chromosome map based on your data.
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Drosophila geneticists made the first genetic maps. They claimed that the gene loci that they mapped “behaved mathematically as though they were in linear order” in the genetic material. They did not claim that these loci were actually physically located in a line along the chromosome.
1. Given what was known about chromosomes and the genetic material at that time, are these statements correct? Why or why not?
In a series of mapping experiments, the recombination frequencies for four different linked genes of the Drosophila fly were determined, as shown in the figure. Based on this information, what is the most probable
order of these genes on the chromosome?
b 0
cn
90
rb
3.5 6.5 0
vg 19 9.0 16 0
b
cn rb vg
The numbers in the boxes are the
recombination frequencies in between the
genes (in percent).
O b-rb-cn-vg
O vg-cn-b-rb
Orb-cn-vg-b
b = black body
cn = cinnabar eyes
rb = reduced bristles
vg = vestigial wings
O vg-b-rb-cn
You design Drosophila crosses to provide recombinationdata for gene a, which is located on the chromosome shownin Figure 15.12. Gene a has recombination frequencies of14% with the vestigial wing locus and 26% with the browneye locus. Approximately where is a located along thechromosome?
Chapter 12 Solutions
Campbell Biology in Focus (2nd Edition)
Ch. 12.1 - Which one of Mendels laws relates to the...Ch. 12.1 - MAKE CONNECTIONS Review the description of meiosis...Ch. 12.1 - WHAT IF? Propose a possible reason that the first...Ch. 12.2 - A white-eyed female Drosophila is mated with a...Ch. 12.2 - Neither Tim nor Rhoda has Duchenne muscular...Ch. 12.2 - MAKE CONNECTIONS Consider what you learned about...Ch. 12.3 - When two genes are located on the same chromosome,...Ch. 12.3 - For each type of offspring of the testcross in...Ch. 12.3 - WHAT IF? Genes A, B, and C are located on the same...Ch. 12.4 - About 5% of individuals with Down syndrome have a...
Ch. 12.4 - WHAT IF? The ABO blood type locus has been mapped...Ch. 12.4 - MAKE CONNECTIONS The gene that is activated on the...Ch. 12.4 - Women born with an extra X chromosome (XXX) are...Ch. 12 - A man with hemophilia (a recessive, sex-linked...Ch. 12 - Pseudohypertrophic muscular dystrophy is an...Ch. 12 - A space probe discovers a planet inhabited by...Ch. 12 - Using the information from problem 3, scientists...Ch. 12 - A man with red-green color blindness (a recessive,...Ch. 12 - You design Drosophila crosses to provide...Ch. 12 - A wild-type fruit fly (heterozygous for gray body...Ch. 12 - Assume that genes A and B are 50 map units apart...Ch. 12 - Prob. 9TYUCh. 12 - SCIENTIFIC INQUIRY DRAW IT Assume you are mapping...Ch. 12 - FOCUS ON EVOLUTION Crossing over is thought to be...Ch. 12 - FOCUS ON INFORMATION The continuity of life is...Ch. 12 - SYNTHESIZE YOUR KNOWLEDGE Butterflies have an X-Y...
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- In an electrophoretic gel across which is applied a powerful electrical alternating pulsed field, the DNA of the haploid fungus Neurospora crassa (n = 7) moves slowly but eventually forms seven bands, which represent DNA fractions that are of different sizes and hence have moved at different speeds. These bands are presumed to be the seven chromosomes. How would you show which band corresponds to which chromosome?arrow_forwardIn the lab, you discover two yeast haploid mutants that cannot produce arginine. You cross them together and the resulting diploid produces arginine. If producing arginine is the wild type phenotype, what can you definitively conclude? A.The haploid strains have identical mutations in the same genes. B.The haploid strains have identical mutations in different genes. C.The haploid strains have mutations in different genes. D.The haploid strains have mutations in the same gene. E.The haploid strains must belong to the complementation group encoding the first enzyme in the biosynthetic pathway.arrow_forwardThe mutations called bobbed in Drosophila result from variable reductions (deletions) in the number of amplified genes coding for rRNA. Researchers trying to maintain bobbed stocks have often documented their tendency to revert to wild type in successive generations. Propose a mechanism based on meiotic recombination which could account for this reversion phenomenon. Why would wild-type flies become more prevalent in Drosophila cultures?arrow_forward
- In Drosophila (fruit flies), pink eyes (P), curled wings (C), a hairy body (H), and an ebony body (E) are determined by genes located on the same chromosome. Gene Combination Recombination Frequency E/H 41.7% C/H 18.2% E/P 22% H/P 19.7% Which of the following gene maps shows the gene sequence on this chromosome?arrow_forwardConstruct a genetic map using the following data: A line of drosophila has been constructed with three recessive mutations: sc = loss of thorax bristles ("scute") ec = roughened eye surface ("echinus") vg = vestigial wings The dominant, wild-type version of each allele could be written as vg + or ec+, but we will write them just as "+" for simplicity. P generation: We cross homozygous recessive flies (sc ec vg / sc ec vg) with homozygous dominant (wild-type) flies (+ + + / + + +). F1 generation: All of the flies produced by the parental cross have the dominant (wild-type) phenotype. Genetically, these flies are: (sc ec vg / + + + ). F2 generation: We produce an F2 generation by mating the F1 flies with homozygous recessive flies (sc ec vg / sc ec vg) This cross produces an F2 generation with 8 different phenotypes: All wild type features – 430 echinus – 5 echinus, vestigial – 29 scute – 25 scute, echinus – 44 scute, echinus, and vestigial – 417 scute,…arrow_forwardThe genome of Drosophila has been studied extensively using the technique of gene mapping. In Drosophila, pink eyes (P), curled wings (C), hairy body (H), and ebony body (E) are determined by alleles of genes located on the same chromosome. Gene Combination E/H C/H E/P H/P Frequency of Recombination 44% 23% 23% 21% Draw a gene map showing the correct order these genes appear on the chromosome. How frequently are the genes for pink eyes and curled wings expected to separate during crossing over?arrow_forward
- Researchers have discovered that some regions of chromosomes are more likely than others to cross over, these areas of frequent crossing over are called "recombination hot spots". Gene A and B are 500,000 bp apart - both genes and the space between them are in a recombination hot spot. Gene C and D are also 500,000 bp apart but the region containing genes C and D are not a recombination hot spot. Would the map distance between A and B be the same as the map distance between C and D? Explain your answer.arrow_forwardThe normal sequence of nine genes on a certainDrosophila chromosome is 123 • 456789, where the dotrepresents the centromere. Some fruit flies were foundto have aberrant chromosomes with the followingstructures:a. 123 • 476589 c. 1654 • 32789b. 123 • 46789 d. 123 • 4566789Name each type of chromosomal rearrangement, anddraw diagrams to show how each would synapse withthe normal chromosome.arrow_forwardThe genetic map was based on crosses in Drosophila involving the three sex-linked genes a, b and c. “a” gives red eyes, “b” gives normal wings and “c” gives black body. The recombination frequencies between these genes are as follows; a and b is 23.8, b and c is 2.6 and a and c is 28.1, respectively. Could you draw a basic genetic map based on distance between these genes using dots to show distance(s)? Could you make one fundamental comment using these distances based on genetic linkage?arrow_forward
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