EBK HUMAN ANAT.+PHYSIOLOGY
11th Edition
ISBN: 9780134807362
Author: Marieb
Publisher: PEARSON CO
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Textbook Question
Chapter 11, Problem 1CCS
Nursing Student with Neuropathic Pain
Tamara Costa broke her right tibia and has undergone two separate surgeries to repair it. Although the bone has healed, she suffers increasing pain around the incision sites. The painful area covers the lateral surface of her right leg. She can't stand wearing anything over it or even having a sheet touch it. Her diagnosis is postsurgical neuropathic pain. Pain medication has not helped.
Tamara is a second-year nursing student and has done some reading to try to understand her problem and perhaps find a solution. She has found an article that says neuropathic pain may be caused by a decreased threshold for action potential generation in pain-detecting neurons. However, she has forgotten some of her physiology and needs some help in understanding what she is reading. She has logged into the “Ask a Nurse" chat line–and she got you!
1. NCLEX-STYLE Tamara asks about action potential thresholds, so you begin by asking her what she knows about the topic. Which statement indicates an area where she needs further instruction?
a.“Threshold is the voltage at which the nerve actually fires an action potential.”
b.“Sodium is entering the nerve cell at threshold, but it was entering before too.”
c.“They call it threshold when the pain gets so bad the painkillers won't stop it, but I always have that!”
d.“I know that what happens at threshold is called depolarization.”
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Chapter 11 Solutions
EBK HUMAN ANAT.+PHYSIOLOGY
Ch. 11 - Prob. 1RQCh. 11 - 2. Match the names of the supporting cells found...Ch. 11 - 4. Assume that an EPSP is being generated on the...Ch. 11 - 5. The velocity of nerve impulse conduction is...Ch. 11 - 6. Chemical synapses are characterized by all of...Ch. 11 - Prob. 5RQCh. 11 - Prob. 6RQCh. 11 - 9. Inhibition of acetylcholinesterase by poisoning...Ch. 11 - 8. The anatomical region of a multipolar neuron...Ch. 11 - 11. An IPSP is inhibitory because (a) it...
Ch. 11 - 12. Identify the neuronal circuits described by...Ch. 11 - 13. Explain both the anatomical and functional...Ch. 11 - 14. (a) Describe the composition and function of...Ch. 11 - 15. (a) What is myelin? (b) How does the...Ch. 11 - 16. (a) Contrast unipolar, bipolar, and multipolar...Ch. 11 - 17. What is the polarized membrane state? How is...Ch. 11 - 18. Describe the events that must occur to...Ch. 11 - 19. Since all APs generated by a given nerve fiber...Ch. 11 - 20. (a) Explain the difference between an EPSP and...Ch. 11 - 21. Since at any moment a neuron is likely to have...Ch. 11 - Prob. 22RQCh. 11 - Prob. 13RQCh. 11 - 25. Briefly describe the three stages of neuron...Ch. 11 - 2. Local anesthetics block voltage-gated Na+...Ch. 11 - 3. When admitted to the emergency room, Sean was...Ch. 11 - 4. Rochelle developed multiple sclerosis when she...Ch. 11 - 5. In the Netherlands a young man named Jan was...Ch. 11 - Nursing Student with Neuropathic Pain Tamara Costa...Ch. 11 - Nursing Student with Neuropathic Pain Tamara Costa...Ch. 11 - Nursing Student with Neuropathic Pain
Tamara...Ch. 11 - Nursing Student with Neuropathic Pain Tamara Costa...Ch. 11 - Nursing Student with Neuropathic Pain Tamara Costa...
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