Human Anatomy
9th Edition
ISBN: 9780135168059
Author: Marieb, Elaine Nicpon, Brady, Patricia, Mallatt, Jon
Publisher: Pearson Education, Inc.,
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Textbook Question
Chapter 11, Problem 11RQ
The major muscles used in the up portion of a chin-up are the (a) triceps brachii and pectoralis major, (b) infraspinatus and biceps brachii, (c) serratus anterior and external oblique, (d) latissimus dorsi and brachialis.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 11 Solutions
Human Anatomy
Ch. 11 - Name the fascicle arrangement in a muscle whose...Ch. 11 - Prob. 2CYUCh. 11 - Which types of leavers operate at a mechanical...Ch. 11 - In a skeletal/muscular lever system, what...Ch. 11 - Most skeletal muscles of the body operate at a...Ch. 11 - Biceps brachii and brachialis both flex the...Ch. 11 - A muscle that abducts the thigh would cross the...Ch. 11 - At most joints (the knee and ankle are...Ch. 11 - Prob. 9CYUCh. 11 - Prob. 10CYU
Ch. 11 - Prob. 11CYUCh. 11 - Prob. 12CYUCh. 11 - Prob. 13CYUCh. 11 - Use your knowledge of word roots and the criteria...Ch. 11 - Prob. 15CYUCh. 11 - Describes the six movements possible at the...Ch. 11 - What muscle is the prime mover of dorsiflexion?...Ch. 11 - How do the lesser gluteals—gluteus medius and...Ch. 11 - Where is the linea alba located, and what muscles...Ch. 11 - Define the boundaries of the triangle of...Ch. 11 - Prob. 21CYUCh. 11 - Identify the body region where the following...Ch. 11 - Prob. 23CYUCh. 11 - Prob. 24CYUCh. 11 - Prob. 1RQCh. 11 - Prob. 2RQCh. 11 - Match the muscles in column B to their embryonic...Ch. 11 - The muscle that closes the eyes is (a) the...Ch. 11 - Prob. 5RQCh. 11 - Prob. 6RQCh. 11 - Prob. 7RQCh. 11 - Prob. 8RQCh. 11 - Prob. 9RQCh. 11 - Prob. 10RQCh. 11 - The major muscles used in the up portion of a...Ch. 11 - Prob. 12RQCh. 11 - Prob. 13RQCh. 11 - Define and distinguish first-, second-, and...Ch. 11 - (a) Name the four pairs of muscles that act...Ch. 11 - List all six possible movements of the humerus...Ch. 11 - (a) Name two forearm muscles that are both...Ch. 11 - (a) Name the lateral rotators of the hip. (b)...Ch. 11 - Prob. 6SAEQCh. 11 - Define (a) a fascial compartment in a limb and (b)...Ch. 11 - Name two muscles in each of the following...Ch. 11 - Prob. 9SAEQCh. 11 - Prob. 10SAEQCh. 11 - Deduce some characteristics of the following...Ch. 11 - For the following muscles, list one action of...Ch. 11 - (a) Define palpation. (b) Why is a knowledge of...Ch. 11 - Explain how one locates the proper site for...Ch. 11 - Prob. 15SAEQCh. 11 - Name the borders of the triangle of auscultation.Ch. 11 - Prob. 17SAEQCh. 11 - Prob. 1CRCAQCh. 11 - Prob. 2CRCAQCh. 11 - Assume you are trying to lift a heavy weight off...Ch. 11 - Prob. 4CRCAQCh. 11 - Prob. 5CRCAQCh. 11 - Based on its fascicle orientation, determine...Ch. 11 - Prob. 7CRCAQCh. 11 - What class of lever is described by the following...Ch. 11 - Walking to her car after her 65th birthday party,...Ch. 11 - An athletic trainer was examining a college...
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