EBK MICROBIOLOGY:W/DISEASES BY BODY...-
EBK MICROBIOLOGY:W/DISEASES BY BODY...-
5th Edition
ISBN: 9780134608242
Author: BAUMAN
Publisher: PEARSON
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Chapter 1, Problem 2CT

In 1911, the Polish scientist Casimir Funk proposed that a limited diet of polished white rice (rice without the husks) caused beriberi, a disease of the central nervous system. Even though history has proven him correct—beriberi is caused by a thiamine deficiency, which in his day resulted from unsophisticated milling techniques that removed the thiamine-rich husks—Funk was criticized by his contemporaries, who told him to find the microbe that caused beriberi. Explain how the prevailing scientific philosophy of the day shaped the point of view of Funk’s detractors.

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In 1971, Dr. Akira Endo, working at the Sankyo company in Tokyo speculated that fungi not only contained antibiotics but also inhibitors of other processes such as cholesterol metabolism. Over a period of several years, he screened more than 6,000 fungal cultures until a positive result emerged. This compound, which was named compactin, came from the blue-green mold Penicillium citrinum Pen-5 that was isolated from a rice sample collected at a grain shop in Kyoto. Based on biochemical assays, compactin is the first known statin. 1. The original kinetics data for compactin inhibition of HMG-CoA reductase enzyme that was published by Dr. Endo in 1976 is shown on the right. a) Determine the Km and Vmax values for enzymatic activity. Do NOT forget the units. Answers can be expressed either as a fraction or in decimals. With No inhibitor: ; Vmax= -60 1/V, (nanomoles/min)-1 0.4 0.35+ 0.3 0.25 0.2 0.15 0.1 0.05 -40 -20 0 + 24 nM compactin + 70 nM compactin None T 20 40 60 1/[HMG-CoA], (mM)-1…
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Chapter 1 Solutions

EBK MICROBIOLOGY:W/DISEASES BY BODY...-

Ch. 1 - Prob. 6MCCh. 1 - Prob. 7MCCh. 1 - Prob. 8MCCh. 1 - A scientist who studies the role of microorganisms...Ch. 1 - The laboratory of Robert Koch contributed which of...Ch. 1 - Fill in the Blanks 1. Environmental microbiology...Ch. 1 - Prob. 2FIBCh. 1 - Fill in the Blanks 3. Chemotherapy _______________Ch. 1 - Fill in the Blanks 4. Immunology _______________Ch. 1 - Fill in the Blanks 5. Infection control...Ch. 1 - Fill in the Blanks 6. Etiology _______________Ch. 1 - Fill in the Blanks 7. Epidemiology _______________Ch. 1 - Fill in the Blanks 8. Biotechnology...Ch. 1 - Fill in the Blanks 9. Food microbiology...Ch. 1 - Why was the theory of spontaneous generation a...Ch. 1 - Discuss the significant difference between the...Ch. 1 - List six types of microorganisms.Ch. 1 - Defend this statement: The investigations of...Ch. 1 - Why would a macroscopic tapeworm be studied in...Ch. 1 - Describe what has been called the Golden Age of...Ch. 1 - List four major questions that drive...Ch. 1 - Refer to the four steps in the scientific method...Ch. 1 - Prob. 9SACh. 1 - What does the term HAI (nosocomial infection) have...Ch. 1 - Match each of the following descriptions with the...Ch. 1 - Prob. 1VICh. 1 - Show where microbes ended up in Pasteurs...Ch. 1 - If Robert Koch had become interested in a viral...Ch. 1 - In 1911, the Polish scientist Casimir Funk...Ch. 1 - Haemophilus influenzae does not cause flu, but it...Ch. 1 - Just before winter break in early December, your...Ch. 1 - Design an experiment to prove that microbes do not...Ch. 1 - Prob. 6CTCh. 1 - Compare and contrast the investigations of Redi,...Ch. 1 - If you were a career counselor directing a student...Ch. 1 - A few bacteria produce disease because they derive...Ch. 1 - How might the debate over spontaneous generation...Ch. 1 - French microbiologists, led by Pasteur, tried to...Ch. 1 - Why arent Kochs postulates always useful in...Ch. 1 - Albert Kluyver said, From elephant to ......Ch. 1 - The ability of farmers around the world to produce...Ch. 1 - Using the following terms, fill in the following...
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