Unit Operations Of Chemical Engineering
7th Edition
ISBN: 9789339213237
Author: MCCABE, WARREN
Publisher: Tata McGraw-Hill Education India
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Chapter 1, Problem 1.16P
Interpretation Introduction
Interpretation:The number of molecules of oxygen in a pound mole of air at
Concept introduction: The number of molecules of any atom in a molecule is calculated by multiplying the number of moles of an atom with the Avogadro number.
The pound mole is to be converted into g mole and kilogram mole is to be converted into g mole.
The formula for calculating number of molecules is
The number of molecules of an atom is not affected by the temperature and pressure.
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Do question 9 please! Question 7 Is just there for reference!!
7) You are tasked with separating two proteins by ion exchange chromatography on a 30 cm long
column with an inner diameter of 2 cm. The resin has a diameter of 100 μm and a void fraction
of 0.3, and your mobile phase flows through the column at a rate of Q = 5 cm³/min. The Van
Deemter coefficients A, B, and C have been determined to be 0.0228 cm, 0.0036 cm²/min, and
0.00053 min, respectively, for both proteins. Protein A elutes from the column with an average
retention time of 27 min and standard deviation of 0.8 min. Protein B elutes from the column.
with an average retention time of 33.8 min and standard deviation of 1.0.
a) How many theoretical plates does the column contain?
b) What flow rate (Q) will give you the maximum resolution?
c) What is the minimum height of a theoretical plate for the system?
4) A fixed bed adsorption unit contains rigid (incompressible) silica particles with a diameter of
120 um and porosity of 0.3. The resin bed is 200 cm long and has a diameter of 15 cm. A protein
solution is pumped into the column at a rate of 50 L/min, and the mobile phase has a viscosity of
1.2 CP.
a) What is the pressure drop for this system (in bar)?
b) What would be the pressure drop if the particle diameter were decreased to 30 μm?
Chapter 1 Solutions
Unit Operations Of Chemical Engineering
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