You discover a new species of poison-dart frog which secretes a neurotoxin in the skin mucous with LD50 of 0.5 mg/kg in humans. The toxin causes numbness, paralysis, arrhythmias, cardiac failure, and death. Based on the patch-clamp record of inward currents when the neurotoxin was applied to squid axon shown in Figure 2, suggest the mechanism of action of the neurotoxin. 500 PA 5 ms Figure 2 (Source: Google image)

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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You discover a new species of poison-dart frog which secretes a neurotoxin in the skin mucous
with LD50 of 0.5 mg/kg in humans. The toxin causes numbness, paralysis, arrhythmias, cardiac
failure, and death. Based on the patch-clamp record of inward currents when the neurotoxin was
applied to squid axon shown in Figure 2, suggest the mechanism of action of the neurotoxin.
500 PA
5 ms
Figure 2 (Source: Google image)
Transcribed Image Text:You discover a new species of poison-dart frog which secretes a neurotoxin in the skin mucous with LD50 of 0.5 mg/kg in humans. The toxin causes numbness, paralysis, arrhythmias, cardiac failure, and death. Based on the patch-clamp record of inward currents when the neurotoxin was applied to squid axon shown in Figure 2, suggest the mechanism of action of the neurotoxin. 500 PA 5 ms Figure 2 (Source: Google image)
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