Experimenters injected increasing amounts of bark scorpion venom into mouse neurons and measured the flow of sodium ions (current) across the cell membrane. The scorpion toxin binds to the voltage-gated sodium channel Nav1.8. What effect does the venom have on Nav1.8 in grasshopper mouse, that allows it to ignore scorpion bark stings?

Experimenters injected increasing amounts of bark scorpion venom into mouse neurons and measured the flow of sodium ions (current) across the cell membrane. The scorpion toxin binds to the voltage-gated sodium channel Nav1.8. What effect does the venom have on Nav1.8 in grasshopper mouse, that allows it to ignore scorpion bark stings?

Curren'S Math For Meds: Dosages & Sol

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ISBN:9781305143531

Author:CURREN

Publisher:CURREN

Chapter14: Formula Method

Section: Chapter Questions

Problem 23SST

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Experimenters injected increasing amounts of bark scorpion venom into mouse neurons and measured the flow of sodium ions (current) across the cell membrane.

The scorpion toxin binds to the voltage-gated sodium channel Nav1.8.

What effect does the venom have on Nav1.8 in grasshopper mouse, that allows it to ignore scorpion bark stings?

House mouse
e Grasshopper mouse
1.07
0.5-
0.0-
-5 -4 -3
-2 -1
log[venom], mg/ml
SCIENCE VOL 342 25 OCTOBER 2013
Fraction of sodium current

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