Experimenters injected increasing amounts of bark scorpion venom into mouse neurons and measured the flow of sodium ions (current) across the cell membrane. The scorpion toxin binds to the voltage-gated sodium channel Nav1.8. What effect does the venom have on Nav1.8 in grasshopper mouse, that allows it to ignore scorpion bark stings?

Essentials of Pharmacology for Health Professions
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ISBN:9781305441620
Author:WOODROW
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Chapter5: Abbreviations And Systems Of Measurement
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Experimenters injected increasing amounts of bark scorpion venom into mouse neurons and measured the flow of sodium ions (current) across the cell membrane. 

The scorpion toxin binds to the voltage-gated sodium channel Nav1.8. 

What effect does the venom have on Nav1.8 in grasshopper mouse, that allows it to ignore scorpion bark stings?

House mouse
e Grasshopper mouse
1.07
0.5-
0.0-
-5 -4 -3
-2 -1
log[venom], mg/ml
SCIENCE VOL 342 25 OCTOBER 2013
Fraction of sodium current
Transcribed Image Text:House mouse e Grasshopper mouse 1.07 0.5- 0.0- -5 -4 -3 -2 -1 log[venom], mg/ml SCIENCE VOL 342 25 OCTOBER 2013 Fraction of sodium current
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