Answered: You are examining the effects of a…

Name: You are examining the effects of a mutation in the proximal histidine
Uploaded: 2024-03-20T06:42:55.000Z
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Description: You are examining the effects of a mutation in the proximal histidine of a heme-containing protein. This mutation has changed the histidine into an alanine. Based on your knowledge of the role of heme in hemoglobin and how it is coordinated in the pr

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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You are examining the effects of a mutation in the proximal histidine of a heme-containing protein. This mutation has changed the histidine into an alanine. Based on your knowledge of the role of heme in hemoglobin and how it is coordinated in the protein, what is the MOST likely effect of the mutation?

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The heme will bind to O2 more effectively than to CO

Heme will no longer be bound in the protein

The iron in heme will be fully coordinated

The iron in heme will have two uncoordinated bonds

There will be no effect on heme binding due to this mutation

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