You are designing a phage therapy for a cystic fibrosis patient with an multi-antibiotic resistant Mycobacterium infection. The Mycobacterium infection is preventing the patient from taking immunosuppressant drugs that are needed for a successful lung transplant. The idea is that introducing the right phage to the patient will kill the Mycobacterium cells and allow the patient to go on immunosuppressant drugs that will ensure the new lung is not rejected by the body.  You need to find a phage that infects the Mycobacterium you isolated from the patient. Which TWO options have the highest chance of success?   Group of answer choices 1.Isolating new phage from soil using a plaque assay with the Mycobacterium isolate 2.Choosing likely candidates from analysis of phage 16S rRNA phylogeny in the tree of life 3.Obtaining a very well-studied phage, such as T4 bacteriophage, that specifically targets E. coli 4.Screening a colleague's library of known Mycobacterium phages for phage that infect the patient's Mycobacterium isolate

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Viral Infections

Viruses are abundantly found, minute entities that have genetic material enclosed within a protein coat. The proteinaceous material enclosing the genetic material of the virus is called a capsid. The genetic material could be either DNA (deoxyribonucleic acid) or RNA (ribonucleic acid). A virus is too minute to be looked at with naked eyes and therefore visualized with the help of a microscope. They are acellular entities that require a host for processes, such as replication, transcription, translation and multiplication. Plants, animals, and bacteria act as host wherein the virus reproduce. Viruses cannot multiply outside the host's body and thus are considered nonliving outside the host body.