You are attempted to purify a compound via column chromatography. Before starting the process, you determine the eluent solvent conditions using TLC. Upon running a TLC you determine the following: 1) In pure hexanes the Rf of your desired compound is 0.10 and the major impurity Rf is 0.15. 2) In pure ethyl acetate the Rf of your desired compound is 0.95 and the impurity comes to the eluent line. 3) in 90:10 hexanes:ethyl acetate the Rf of your desired compound is 0.40 and the impurity at 0.90. Which of these eluents would you use to run your column? Neat hexanes Neat ethyl acetate 90:10 hexanes:ethyl acetate Water

You are attempted to purify a compound via column chromatography. Before starting the process, you determine the eluent solvent conditions using TLC. Upon running a TLC you determine the following: 1) In pure hexanes the Rf of your desired compound is 0.10 and the major impurity Rf is 0.15. 2) In pure ethyl acetate the Rf of your desired compound is 0.95 and the impurity comes to the eluent line. 3) in 90:10 hexanes:ethyl acetate the Rf of your desired compound is 0.40 and the impurity at 0.90. Which of these eluents would you use to run your column? Neat hexanes Neat ethyl acetate 90:10 hexanes:ethyl acetate Water

EBK A SMALL SCALE APPROACH TO ORGANIC L

4th Edition

ISBN:9781305446021

Author:Lampman

Publisher:Lampman

Chapter88: Column Chromatography

Section: Chapter Questions

Problem 4P

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