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- (c) Which phase of cell growth is disrupted by antimetabolites? Explain how as folate methotrexate functions antagonist. antimabolitesDescribe the effects of competitive, uncompetitive, and mixed inhibitors onKM and Vmax.One of the following glycosaminoglycans is anti-coagulant O Heparan sulphate O Hyaluronic acid O Heparin sulphate O Keratan sulphate O Chondroitin sulfate search
- Which statement on the biosynthesis of cannabinoids is NOT TRUE? Select one: O a. Geranyl pyrophosphate is formed as a precursor via the deoxyxylulose pathway in cannabis O b. Divarinic acid is the precursor for the production of propyl cannabinoid acids. O C. When prenyl-transferase enzyme uses olivetolic acid as substrate cannabigerivarinic acid (CBGVA) is formed. O d. THCA-synthase, CBDA-synthase, and CBC- synthase enzymes can use both CBGA and GBGVA as substrate.A schematic representation of the enzyme IspD complexed to inhibitor 3, and a series of inhibitors 3-5 are shown below. Ala202 lle240 mwww NH NH Val263 ОН www HN N- lle177 HN 'N' CI 3 X = N 4 X = C-CN 5 X = C-COO IC50 274 µM IC50 140 nM IC50 35 nM NH2 HN Val266 N -N O-H---- N HN %3D Arg157 HN wwww lle265 Explain why structure 4 is a more potent inhibitor (lower IC50 value) than inhibitor 3 and why structure 5 is a much weaker inhibitor (higher IC50 value) than 3 and 4.Polyethylene glycol (PEG)-conjugated IFNs have superior pharmaceutical properties compared with their unconjugated counterparts as a result of greater protection against proteolytic degradation, better solubility, and slower catabolism and excretion. Group of answer choices True False
- Describe the mechanism of toxicity of P=S organophosphates insecticides (e. g. parathion) in the body of an insectWhat is the mechanism of action of piperacillin-tazobactam(zosyn)Latrotoxin identify the species which releases the toxin (if it is man-made then this will be all that is required for this part) identify the step disrupted in the neuromuscular junction pathway Provide any consequences of this disruption. Does the toxin have any applications in biomedicine as a painkiller, disease treatment or analgesic? Provide your source in APA format for each. If this is missing no credit will be awarded.