Would increasing the concentration of glucose be a physiologically reasonable way to increase the concentration of G6P? Yes. [Glucose] is lower than [G6P], so adding glucose would shift the equilibrium to the right. No. The glucose concentration would need to be higher than the maximum solubility of glucose. No. Because the concentration of Pi is lower than the concentration of glucose, Pi is the limiting reactant. Yes. The glucose concentration would be higher than the concentration of G6P, so the reaction would proceed.
Would increasing the concentration of glucose be a physiologically reasonable way to increase the concentration of G6P? Yes. [Glucose] is lower than [G6P], so adding glucose would shift the equilibrium to the right. No. The glucose concentration would need to be higher than the maximum solubility of glucose. No. Because the concentration of Pi is lower than the concentration of glucose, Pi is the limiting reactant. Yes. The glucose concentration would be higher than the concentration of G6P, so the reaction would proceed.
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
Related questions
Question
Answer this Question
Would increasing the concentration of glucose be a physiologically reasonable way to increase the concentration of G6P?
Yes. [Glucose] is lower than [G6P], so adding glucose would shift the equilibrium to the right.
No. The glucose concentration would need to be higher than the maximum solubility of glucose.
No. Because the concentration of Pi is lower than the concentration of glucose, Pi is the limiting reactant.
Yes. The glucose concentration would be higher than the concentration of G6P, so the reaction would proceed.
![The phosphorylation of glucose to glucose 6-phosphate is the initial step in the catabolism of glucose. The direct
phosphorylation of glucose by P, is described by the equation
Glucose + P₁ glucose 6-phosphate + H₂O
In principle, at least, one way to increase the concentration of glucose 6-phosphate (G6P) is to drive the equilibrium reaction to
the right by increasing the intracellular concentrations of glucose and P₁.
AG'° = 13.8 kJ/mol
The maximum solubility of glucose is less than 1 M, and the normal physiological concentration of G6P is 250 μM. Assume a
fixed concentration of P, at 4.8 mM. The calculated value of K'eq is 4.74 x 10-³ M-¹.
Calculate the intracellular concentration of glucose when the equilibrium concentration of glucose 6-phosphate is 250 μM, the
normal physiological concentration.
[glucose] =
11
M](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Fe31029a8-64b8-4001-b02b-a4ced2e71261%2F6701f4c9-25d9-4092-82ee-2652a9898972%2Ftajmdej_processed.jpeg&w=3840&q=75)
Transcribed Image Text:The phosphorylation of glucose to glucose 6-phosphate is the initial step in the catabolism of glucose. The direct
phosphorylation of glucose by P, is described by the equation
Glucose + P₁ glucose 6-phosphate + H₂O
In principle, at least, one way to increase the concentration of glucose 6-phosphate (G6P) is to drive the equilibrium reaction to
the right by increasing the intracellular concentrations of glucose and P₁.
AG'° = 13.8 kJ/mol
The maximum solubility of glucose is less than 1 M, and the normal physiological concentration of G6P is 250 μM. Assume a
fixed concentration of P, at 4.8 mM. The calculated value of K'eq is 4.74 x 10-³ M-¹.
Calculate the intracellular concentration of glucose when the equilibrium concentration of glucose 6-phosphate is 250 μM, the
normal physiological concentration.
[glucose] =
11
M
Expert Solution
This question has been solved!
Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.
This is a popular solution!
Trending now
This is a popular solution!
Step by step
Solved in 2 steps
Recommended textbooks for you
Biochemistry
Biochemistry
ISBN:
9781319114671
Author:
Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:
W. H. Freeman
Lehninger Principles of Biochemistry
Biochemistry
ISBN:
9781464126116
Author:
David L. Nelson, Michael M. Cox
Publisher:
W. H. Freeman
Fundamentals of Biochemistry: Life at the Molecul…
Biochemistry
ISBN:
9781118918401
Author:
Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher:
WILEY
Biochemistry
Biochemistry
ISBN:
9781319114671
Author:
Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:
W. H. Freeman
Lehninger Principles of Biochemistry
Biochemistry
ISBN:
9781464126116
Author:
David L. Nelson, Michael M. Cox
Publisher:
W. H. Freeman
Fundamentals of Biochemistry: Life at the Molecul…
Biochemistry
ISBN:
9781118918401
Author:
Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher:
WILEY
Biochemistry
Biochemistry
ISBN:
9781305961135
Author:
Mary K. Campbell, Shawn O. Farrell, Owen M. McDougal
Publisher:
Cengage Learning
Biochemistry
Biochemistry
ISBN:
9781305577206
Author:
Reginald H. Garrett, Charles M. Grisham
Publisher:
Cengage Learning
Fundamentals of General, Organic, and Biological …
Biochemistry
ISBN:
9780134015187
Author:
John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. Peterson
Publisher:
PEARSON