Workshop 3 Topic: Bio-isosteres and derivatives 1. Carefully examine the below drug, and suggest two bio-isosteric modifications for the heterocyclic ring in furosemide without changing activity. 00 0 H₂N S O b OH a ZI N N C H N CI Furosemide Ring name Ring Physicochemical properties P NI ZI N e Suitability as bio-isosteres

Workshop 3 Topic: Bio-isosteres and derivatives 1. Carefully examine the below drug, and suggest two bio-isosteric modifications for the heterocyclic ring in furosemide without changing activity. 00 0 H₂N S O b OH a ZI N N C H N CI Furosemide Ring name Ring Physicochemical properties P NI ZI N e Suitability as bio-isosteres

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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3. What is the main product for each of the following reactions? (a) p-Methylanisole + CH3CH₂COCI, AICI3 -> ? (b) Toluene + Br₂, light, then CH3CH₂COCI, AICI 3 -> ? -> ? (c) Acetophenone + CH³CH₂CI, AICI3, then Br₂, Fe -----> ? (d) Styrene + CH3CH₂COCI AICI3, then Br2, Fe (e) Benzene + 1-chloro-2,2-dimethylpropane, AlCl3 ----> ? (f) Benzene + 3-phenyl-1-propene, H₂SO4, heat > ? (g) Toluene + 1-phenyl-3,3-dimethyl-2-butanol, H₂SO4, heat (h) Benzene + HCOCI, AICI3 then 1-chlorobutane, AlCl3 - ? ‒‒‒‒
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(b) The 1H-NMR spectrum of compound B, C5 H10 O2, consists of the following signals: 8 1.2 (d, 6H), 2.0 (s, 3H), and 5 (septet, 1H); contains an ester. Draw the structural formula of compound B. • You do not have to consider stereochemistry. • Explicitly draw all H atoms. ୫) C n ? ChemDoodle ® Show Hint
+ Module 10 HW Chapter 20 - Selected Exercises Question 3 of 7 -/1 E Draw the major product(s) formed when cyclopentanecarboxylic acid is treated with each of the following reagents: with SOCI2: * Draw Your Solution Q Mu eTextbook and Media Que Fill in with LIAIH, (excess), followed by HạO": Ques Multipa MacBook Air esc 000 F4 トト FI F2 F3 FS F6 F7 %23 %24 % & * 2 4 5 6 8 W E R T Y tab S D F K caps lock C shift alt control option command CO >