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- Assume that the water side product is continuously removed to drive the reaction toward products. CH3NH2, TSOH CWhat is the best reason why carboxylic acid 3 is the most acidic? aioH cioH а он дон CI- OH OH 1 || F ||| IV A) It is the least sterically hindered. B) The F groups are good leaving groups. C) F is very electronegative and can stabilize a negative charge as FO. D) F is very electronegative and will help to stabilize a negative charge on oxygen via induction. E) The conjugate base is stabilized by resonance.The following reactions will not produce the product given. Explain Briefly why. You may use pictures in your explanation.