2. a.Compound D, Figure 5, can undergo a palladium catalysed cyclisation to givecompound E.BugSnPhOTfPd(PPh3)4C25H26LiClEDFigure 5(i)Name the reaction generating compound E from compound D.(ii) Discuss the catalytic cycle for the formation of compound E.(iii) Briefly explain the role of the LiCl additive in Figure 5.(iv) Draw the structure of compound E.[[Co

Step 1: Step 2: Step 3: Step 4:

Answered: 2. a. Compound D, Figure 5, can undergo…

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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G.267.
Paragraph 10. Answer ALL parts of this question. Treatment of acetylcyclopentane (see Scheme Q10a) with NaOEt in ethanol at 25 °C results in formation of a major, thermodynamic enolate (Scheme Q10a). NaOEt Thermodynamic enolate ELOH 25 °C (Scheme Q10a) (a) Draw the structure of the thermodynamic enolate. (b) Explain why the enolate in answer (a) is the major enolate present in the equilibrium at room temperature. (C) Draw the product formed when the thermodynamic enolate (1 mole) reacts with ethyl acrylate (1 mole) (Scheme Q10c). OEt + NaOEt Thermodynamic enolate Product ETOH 25 °C C12H2003 (Scheme Q10c) (d) Draw the kinetic product formed when 1-cyclopentene-1-carbaldehyde reacts with sodium cyanide at low temperature (5 °C) and over a short reaction time (5 minutes) (Scheme Q10d). NACN Kinetic product ELOH 5 °C (Scheme Q10d) >
3. following reactions. (a) Draw the product(s) including its(their) stereochemistry in each of the H20 (6) Br cI :8=c-H (i) 1. SOCI, OH 2. CH300 HBr (aq.) (iv) (b) Draw a stepwise mechanism for the formation of products in the reaction below. OH Br (c) Device a synthesis of the product from the given starting material for the following transformation. More than one step is required. ÇI HO.
For EACH of the following reactions (a)-(d) provide a curved arrow mechanism and where appropriate briefly comment on any issues of selectivity that arise. (a) (b) (c) CHO MeO OMe 3 OH MeO NH OEt Me (i) Ph3P=CBr2 (ii) "BuLi (2 equivs) (iii) Mel + H₂SO4 (cat) OMe H₂O Me3Si * TfO OMe O MeCN CO₂Me MeO CsF, NaHCO3 Me COMe OMe
4. (a) (i) Draw the mechanism with three-dimensional conformations and identify the product for the solvolysis (SN1) reaction between compound (A) and acetic acid (CH3CO₂H). Me (A) OTS H (B) OTS (ii) Predict, with reasoning, whether compound (A) or compound (B) will undergo solvolysis faster.
6. Complete the following reaction scheme (а) hv Br2 (b) hv NBS ÇCL4, (a solvent) (c) H2 Pd/C
Q4. Nucleophilic attack at carbonyl with loss of carbonyl oxygen. For this question, answer AT LEAST FIVE of the SIX parts. (a) For the FOUR reactions listed below, draw structures of the major organic products. (i) (ii) (iii) HO OH ●... NMe₂NH₂ cat. dry HCI H Ph₂pⓇ THF
Predict the major products of each of the following reactions. (a) (b) CI CI Br. (CH),COK NaBr ? DMSO ? DMF
(a) A student was given a task to synthesize the products as shown below. Analyze the reaction schemes below and state whether the reaction conditions supplied in each reaction scheme will result in the products shown as MAJOR PRODUCTS. If wrong products are shown, draw the correct products and provide mechanistic details (curly arrows) of how the right (major) products were formed. (i) (ii) (iii) CI 20 ******* HI t-BuOK t-BuOH NaOEt EtOH, 70 °C Diethyl ether
(b) Describe the hazards of (i) trioxygen: (ii) hydroxide ion; (ii) hydrogen sulfide. (c) Explain why an aqueous solution of sodium sulfide has an odor of hydrogen sulfide. (d) (11) Reduction of H,CCHCHO with NABH4 gives a product different from that of catalytic hydrogenation (H2 /Ni). What are the products?
Give detailed Solution with explanation needed..please explain
6. a) The structural formulae of three isomers are shown below. - -CH2CH, CHO A OCH₂CCH3 B C-CH₂CH3 C With the aid of equations, describe the reactions of the isomers with i) Hydrazine, NH₂NH2 ii) lodine in an alkaline solution iii) Ammoniacal silver nitrate b) With the aid of equations, state the reagents and conditions required to prepare i) B from 1-phenylpropan-2-ol ii) C from benzene

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