Why would you select an Fmoc group over a Boc group for the protection of the amine shown below? vs O Fmoc groups can be removed under more mild conditions than Boc groups, leading to less degradation of the amino acid or peptide. O Fmoc groups are selectively removed using piperidine, whereas Boc and t-butyl esters are both deprotected non-selectively with TFA. O Boc groups can be removed under more mild conditions than Fmoc groups, leading to less degradation of the amino acid or peptide. O Fmoc groups are selectively removed using TFA, whereas Boc and t-butyl esters are both deprotected non-selectively with piperidine.

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Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
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Chapter1: Chemical Foundations
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Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Why would you select an Fmoc group over a Boc group for the protection of the amine shown
below?
vs
Fmoc groups can be removed under more mild conditions than Boc groups, leading to less
degradation of the amino acid or peptide.
O Fmoc groups are selectively removed using piperidine, whereas Boc and t-butyl esters are
both deprotected non-selectively with TFA.
Boc groups can be removed under more mild conditions than Fmoc groups, leading to less
degradation of the amino acid or peptide.
Fmoc groups are selectively removed using TFA, whereas Boc and t-butyl esters are both
deprotected non-selectively with piperidine.
Transcribed Image Text:Why would you select an Fmoc group over a Boc group for the protection of the amine shown below? vs Fmoc groups can be removed under more mild conditions than Boc groups, leading to less degradation of the amino acid or peptide. O Fmoc groups are selectively removed using piperidine, whereas Boc and t-butyl esters are both deprotected non-selectively with TFA. Boc groups can be removed under more mild conditions than Fmoc groups, leading to less degradation of the amino acid or peptide. Fmoc groups are selectively removed using TFA, whereas Boc and t-butyl esters are both deprotected non-selectively with piperidine.
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