Answered: Why would a drug with a TI of less than…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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A crude extract sample was obtained from a plant and was found effective as an anti-diabetic agent in-vitro. The researcher wants to determine the appropriate lethal dose of the sample because it was intended to be administered orally. Literature studies show that plants under the same genus with the source of the crude extract has a lethal dose of 300 mg/Kg BW. Your group performed the test following the OECD Guideline 423 and used the recommended starting dose. The derived approximate LD50 was 25 mg/Kg BW.

Why would a drug with a TI of less than 1 be considered as the primary treatment of a certain disease?

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