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Which of the Pedigree diagrams below is most likely to show a family with Sickle Cell Anaemia?
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- The mother of a family with 10 children has blood typeRh+. She also has a very rare condition (elliptocytosis,phenotype E) that causes red blood cells to be oval rather than round in shape but that produces no adverseclinical effects. The father is Rh− (lacks the Rh+ antigen)and has normal red blood cells (phenotype e). The children are 1 Rh+ e, 4 Rh+ E, and 5 Rh− e. Information isavailable on the mother’s parents, who are Rh+ E andRh− e. One of the 10 children (who is Rh+ E) marriessomeone who is Rh+ e, and they have an Rh+ E child.a. Draw the pedigree of this whole family.b. Is the pedigree in agreement with the hypothesisthat the Rh+ allele is dominant and Rh− is recessive?c. What is the mechanism of transmission ofelliptocytosis?d. Could the genes governing the E and Rh phenotypesbe on the same chromosome? If so, estimate the mapdistance between them, and comment on your resultThe e-gram (graph to the right of allelic ladder image) and above is from a woman. She has variations 14 and 15 at STR D3S1358. If she has children with a man who has variations 12 and 19 at the same STR, what are the possible combinations of variations that their children would have?Which of the Pedigree Diagrams below is most likely to show a family with Hereditary haemorrhagic telangiectasia? A Affected female Normal female Atfected mate ormal male KEY Homozygous Homazygous Heterozygous Heterazygous Wild Type Male Wild Type Female Male Female Female Mala Note: Completely red symbol denotes an individual exhibiting the phenotype of interest C 3 12 1/2 IV 14 14 Affected 12 12 Known camer
- A woman homozygous for normal height, with freckles, almond-shaped eyes, small nose, and Type A blood, has a Type O mother with no freckles and a type AB father with round eyes. She is engaged to a man with achondroplasia, round eyes and medium sized nose. Unlike his father, hismother is of normal height. Both his parents have Type O blood but nobody from both sides of his family has or had freckles. a. Write the COMPLETE genotypes of the man and the woman. Clearly indicate which genotype belongs to whom. b. Based on their genotypes, what is the probability that they will have: b.1 a child with Achondroplasia? b.2 a child of normal height? b.3 a child with type AB blood? b.4 a daughter with round eyes, freckles, and medium sized nose? b.5 a son with almond eyes, no freckles, and small nose?b.6 a daughter with same genotype as the woman? b.7 a son with same genotype as the man?The following pedigree follows the inheritance pattern of sickle cell anemia (b) in a family. What is the sex, genotype, and phenotype of individual II-5? 1 II 2 3 5 2 3 4 5 Unaffected female, Bb Unaffected male, bb Affected male, bb Affected female, Bb Unaffected male, BBA couple are both phenotypically normal but their son suffers from hemophilla, a sex linked recessive disorder. What fraction of their children are likely to suffer from hemophilia. what fraction are likely to be carriers.
- ABO Blood TypeThe following pedigree shows the incidence of ABO blood types in a family. dentify the genotypes of the following individuals: Individual Genotype II-1 II-2 II-4 II-5 III-2 III-3Consider the selfed offspring of a AaBbCcDd individual: What is the probability that offspring will have the following genotypes: AABBCCDD AaBbCCDd ● • A_B_C_D_ BbCCDd ● ● ● ● ● 1/4 x 1/4 x 1/4 x 1/4= 1/256 1/2 x 1/2 x 1/4 x 1/2= 1/32 3/4 x 3/4 x 3/4 x 3/4= 81/256 1 x 1/2 x 1/4 x 1/2= 1/16 Same genotype as the parent? A.1 B. 1/1/12 C. D.1/8 E.1/16к, х Ааv AdBbCc AaBbCc No Spacing AaBbCc 三、相、 1 Normal Heading 1 Font Paragraph 6. Let's assume that the non-taster, daughter in question 5 is a carrier of the albino trait. She marries a Styles taster man, normally pigmented, whose mother was a non-taster albino. Show the cross between these parents. Genotype of the woman Genotype of the man Genotypes Phenotypes What is the chance that their child will be a taster? Footer What is the chance that their child will be albino? What is the chance that their child will be a taster albino? J.S.)
- While sitting at home during Movement Control Order (MCO) because of pandemic covid19, observe two different traits of a couple in your family (eg. your mom & dad or your sister & her husband or your brother & his wife, etc). Draw a genetic cross that involves cross of the parents with the chosen 2 pairs of their contracting traits. Imagine that the cross obeys the Mendelian Laws, show the cross and gametes production for each generation (P, F1 and F2). By Using a Punnet square as symbolic representation of the results for the cross, determine the phenotypes, genotypes, phenotypic ratio and genotypic ratio of F2 generation in the family.1. The pedigree chart in Figure 5.29 shows the inheritance of haemopiu family. Study the pattern of inheritance in the pedigree chart, and then answer the questions that follow. о 5 6. 3 8 9 10 11 Key Unaffected male Haemophiliac male О Unaffected female Fig. 5.29 Pedigree chart of a family affected by haemophilia a) What is the genotype and phenotype of individuals 2 and 4? b) (i) How many of the unaffected family members are definitely carriers of the recessive allele? (ii) How are you able to tell which of the family members are carriers? (4) (1) (3) c) (i) If Individual 11 marries a carrier female, what percentage of their sons is likely to be haemophiliacs? (1) (ii) Use a genetic diagram to show how you worked out your answer in i, (6) 2. Why is haemophilia never passed from father to son, even though it is most common in males? (4) 3. Can a mother pass on a sex-linked gene to her daughter? (1) 4. Sipho has red-green colour blindness. One of his grandfathers was also. colour…Which of the pedigree diagrams below is most likely to show a family with X-linked agammaglobulinemia? A KEY. C Horygon Hamocyga Hezexygess Hey Wild Type fursale Mek Parmak Mais Note: Completely red symbol denotes an individual exhibiting the phenotype of interest H INV V 1/4 1/2 1/2 1.0. 1/2 1/2 1/4 Typ female 1/2 B Affected Known carrier Normal Moral D O To