Which of the following statements best defines the term ‘spare receptors’? ‘Spare receptors’ refers to receptors that are broken down by cells because they are surplus to requirements. ‘Spare receptors’ occur when the KD for agonist binding to the receptor is smaller than the EC50 determined for a particular physiological response. ‘Spare receptors’ refers to the pool of intracellular receptors that are able to translocate to the plasma membrane. ‘Spare receptors’ can be defined as the number of receptors not occupied by agonist when a maximal response has been achieved, compared to the total number of receptors in the cell.

Q: Below are schematics of two cell signalling pathways. Based on these diagrams, which of the…

A: Cell signaling begins at the cell's axon, the extended fiber component of a nerve cell where…

Q: Which of these molecules is most likely to interact with an intracellular receptor? О HO НО H₂N ОН…

A: The cellular receptors are involved in signal transduction processes.Cell surface or membrane…

Q: You perform a competition study on a GPCR. You have isolated the plasma membrane from cells which…

A: GPCR stands for G Protein-Coupled Receptor. It is a type of transmembrane receptor that spans the…

Q: Tumor necrosis factor alpha (TNF-α) is an important cytokine used by immune cells to initiate and…

A: We are given a receptor ligand interaction as shown below.T + R  C'T' is the ligand (TNF-), 'R' is…

Q: Cytokine receptors and tyrosine kinase receptors are similar in all of the following ways EXCEPT…

A: Cytokine receptors are small signaling proteins that help in both immune response and cell…

Q: Do you consider GPCR is intracellular or membrane bound receptor?? Explain it

A: GPCR:  G protein-coupled receptors (GPCRs), also called seven-(pass)-transmembrane domain receptors,…

Q: In this mechanim of receptor regulation, there is uncoupling of the signaling pathway. Even though…

A: Introduction   Receptor regulation is the homeostatic increase or decrease in receptor activity/…

Q: Immediate loss of the Sar1 GTPase activating protein would most likely influence which of the…

A: The immediate loss of the Sar1 GTPase activating protein would most likely influence Sar1…

Q: Imagine being on the TV show Survivor of the Smartest and you are stuck on an island with only a few…

A: The nervous and hormonal systems are in charge of body control and coordination. The neurons are the…

Q: which of the following statements about heterotrimetric G proteins and their receptors is incorrect?…

A: What is G Protein? The G protein is a type of protein that is present in the cytoplasmic region of…

Q: In a cat, guanylyl cyclase (which receptor that receives the first messenger and initiates the cell…

A: Guanylyl cyclase is an enzyme that catalyzes the conversion of GTP (guanosine monophosphate) to cGMP…

Q: Molecule X is a soluble protein that is secreted in response to extracellular signal Y. Which…

A: Cell signaling is referred as Communication between cells .All cells receive and responds to signals…

Q: Different cell types express different types of receptors; even asingle cell may express multiple…

A: Cell signaling is an important mechanism by which cells communicate with each other. Signaling…

Q: Which of the following is the most accurate process? Activation of G protein → change in activity of…

A: G-protein-coupled receptors (GPCRs) are the most numerous and varied class of membrane receptors…

Q: E. coli cells use a two-component system to sense nitrate in the environment. What would happen if…

A: Bacteria‘s are prokaryotic unicellular organisms. Bacterial have incipient nucleus. E.coli is a gram…

Q: Which of the following epidermal growth factor (EGF) receptors cannot bind ligands but will form…

A: Epidermal growth factor (EGF) is a protein that plays a key role in the regulation of cell growth,…

Q: G protein-coupled receptors bind extracellular signals then activates trimeric G proteins inside the…

A: The cell membrane or plasma membrane is the membrane that separates the interior of the cell from…

Q: Put the steps of the process of G-protein signal transduction in the order (1-4) in which they…

A: Proteins are the ultimate products of the genes. DNA is transcribed into m RNA and this is…

Q: In most neurons, membrane depolarization leads to the opening of voltage-dependent ion channels,…

A: The sense organ that allows vision by reacting to light in humans is the eye. Photoreceptor cells…

Q: An SH2-containing protein contains a mutation that changes its binding pocket such that tyrosine and…

A: A class of proteins known as SH2 (Src homology 2) containing proteins is crucial in cell signalling…

Q: An experimental cell line expresses K+ inward rectifier channels, Na+ leak channels, K+ channels…

A: Because alpha-1 adrenergic receptors are found in both vascular smooth muscle and cardiac tissue,…

Q: Which is true about signaling receptors?     They are transmembrane proteins that have binding…

A: Signalling receptors are the transmembrane proteins that span the plasma membrane of the cell. they…

Q: Why do we need to identify and determine the function of every single molecule involved in cell…

A: Cell signaling is an important aspect of biological life. It allows  cells to detect and respond to…

Q: Continuous exposure of a Gαs protein coupled receptor to its ligand leads to a phenomenon known as…

A: In eukaryotes, G protein-coupled receptors (GPCRs) are the most numerous and diverse type of…

Q: Intracellular signaling pathways provide multiple opportunities for the amplification of a response…

A: there are several intracellular signaling pathways works together in a body that regulates normal…

Q: In terms of cell communication, compare and contrast the action of hydrophilic versus hydrophobic…

A: Ligand is defined as the molecule which is produced by a signaling cell that further, binds with a…

Q: You decide to investigate cell signaling of a pair of newly identified GPCRs, GPCR-W and GPCR-Z.…

A: The body of eukaryotic organisms consists of various receptor molecules that bind with signals and…

Q: In Chapter 3, the Kd of calmodulin EF hands for binding Ca2+ is given as 10−6 M. Many proteins have…

A: Calmodulin is a Ca2+ sensor with EF-hands as its high-affinity Ca2+ binding domains, making it a…

Q: In the light of the mechanisms of signal transduction pathways, describe how:  1. the immune system…

A: 1)Immunity is the resistance of the body to fight against foreign agents .the immunity present since…

Q: How can the same signal (ligand) , result in different cellular responses in different cell types…

A: A ligand is an ion, which gives a pair of electrons to the central metal atom or ion to form a…

Q: Which of the following statements about the role of ATP in cell signalling is correct? Choose only…

A: Introduction ATP is adenosine triphosphate, it is a nucleotide that is made up of sugar, phosphate,…

Q: When a signal binds to the Tyrosine kinase receptor (RTK), you have studied that a list of events…

A: Receptor protein-tyrosine kinases is largest family of enzyme linked receptors which phosporylate…

Q: We saw that GPCRs have a basal level of constitutive activity. Not all receptors do. Why might…

A: Introduction:  G-protein coupled receptors (GPCRs) are also known as seven-membrane domain…

Q: Assume that the extracellular hydrophilic signal is acetylcholine. Describe the events that will…

A: G proteins, also known as guanine nucleotide-binding proteins, are a family of proteins involved in…

Q: Describe the process of Signaling by Receptors That Are Ligand-Gated IonChannels?

A: Cells, the most fundamental and vital unit of life, are found in all living things. A cell is in…

Q: An extracellular signaling molecule binds to cell surface receptor. This cell surface receptor…

A: According to the question, An extracellular signaling molecule binds to a cell surface receptor.…

Q: Identify which of the following statements is a lie? Select one: a. The docking of ligands to the…

A: Chemical signaling allows cells to interact with one another. Different substances, like hormones…

Q: You decide to investigate cell signaling of a pair of newly identified GPCRs, GPCR-W and GPCR-Z.…

A: The body of eukaryotic organisms consists of various receptor molecules that bind with signals and…

Q: Briefly explain how integrin inside-out and outside-in signaling is different structurally and…

A: Answer :  The Integrin extraction of heterodimeric cell adhesion receptors now not onlt performs a…

Cell Signaling

It allows cells to perform various cellular activities, coordinate, and interact with other cells. All cells of an organism receive signals from their environments and respond accordingly. Even the unicellular eukaryotes receive signals secreted by other cells and respond. In the case of yeast, mating takes place by signaling between the yeast cells. Communication by cell signaling in a multicellular organism has become a vast and important part of various fields of biology.