It is important for the cell to be able to terminate responses, and diminish responsiveness to prevent overstimulation.  Cells have different mechanisms for this. One such mechanism is receptor down regulation. a.) Down regulation describes a decrease in the availability of hormones or neurotransmitters that bind to receptors on the surface of target cells, making the cells less likely to be stimulated.   b.) Down regulation describes glycosylation of receptor proteins receptors on the surface of target cells in order to decrease the selectivity of ligand binding, making the cells less sensitive to a hormone or neurotransmitter.   c.) Down regulation describes a decrease in the number of receptors on the surface of target cells, making the cells less sensitive to a hormone or neurotransmitter.

Human Anatomy & Physiology (11th Edition)
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Chapter1: The Human Body: An Orientation
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It is important for the cell to be able to terminate responses, and diminish responsiveness to prevent overstimulation.  Cells have different mechanisms for this. One such mechanism is receptor down regulation.

a.) Down regulation describes a decrease in the availability of hormones or neurotransmitters that bind to receptors on the surface of target cells, making the cells less likely to be stimulated.
 
b.) Down regulation describes glycosylation of receptor proteins receptors on the surface of target cells in order to decrease the selectivity of ligand binding, making the cells less sensitive to a hormone or neurotransmitter.
 
c.) Down regulation describes a decrease in the number of receptors on the surface of target cells, making the cells less sensitive to a hormone or neurotransmitter.
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Cell signalling helps cells to coordinate and communicate with one another while performing numerous biological tasks. All cells in a species acquire and react to messages from their surroundings.

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