Which of the following mutations will MOST drastically change the polypeptide sequence for which the DNA codes? 1 base pair change 2 base pair changes 3 consecutive insertions 1 insertion

Name: Which of the following mutations will MOST drastically change the poly
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Description: Which of the following mutations will MOST drastically change the polypeptide sequence for which the DNA codes? 1 base pair change 2 base pair changes 3 consecutive insertions 1 insertion

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Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

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Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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Which of the following mutations will MOST drastically change the polypeptide sequence for which the DNA codes?

1 base pair change

2 base pair changes

3 consecutive insertions

1 insertion

Expert Solution

Step 1 MUTATION

MUTATION

A change in the sequence of DNA or mRNA is known as a mutation.

> The ultimate result of mutated DNA is a changed polypeptide chain than was originally made.

Mutations can be of different types:

❅ Substitution Mutation

occurs when a base pair is substituted by another base pair.
transition mutation occurs when a pyrimidine or purine base is substituted by a pyrimidine or purine base respectively.
transversion mutation occurs when a pyrimidine or purine base is substituted by a purine or pyrimidine base respectively.

❅ Frameshift Mutation

occurs when the reading frame of the polypeptide is changed such that none of the original amino acids are made from the point where the mutation occurs.
deletion occurs when one or more bases are deleted from the mRNA sequence.
insertion occurs when one or more bases are inserted into the mRNA sequence.

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