Which of the following is true of DAG? The DAG pathway allows Ca++/Calmodulin-dependent kinases to phosphorylate other protein targets DAG is in the cytoplasm and releases Ca2+ from the ER DAG binds to IP3 receptors O DAG is in the plasma membrane and activates PKC
Which of the following is true of DAG? The DAG pathway allows Ca++/Calmodulin-dependent kinases to phosphorylate other protein targets DAG is in the cytoplasm and releases Ca2+ from the ER DAG binds to IP3 receptors O DAG is in the plasma membrane and activates PKC
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Transcribed Image Text:### Quiz Question: Understanding DAG in Cell Signaling
#### Question:
**Which of the following is true of DAG?**
#### Options:
1. ○ The DAG pathway allows Ca++/Calmodulin-dependent kinases to phosphorylate other protein targets.
2. ○ DAG is in the cytoplasm and releases Ca2+ from the ER.
3. ○ DAG binds to IP3 receptors.
4. ○ DAG is in the plasma membrane and activates PKC.
#### Explanation:
In cellular signaling, **Diacylglycerol (DAG)** plays a crucial role. DAG is a lipid-derived second messenger involved in signal transduction pathways. Here’s a brief description to help you understand each option:
1. **The DAG pathway allows Ca++/Calmodulin-dependent kinases to phosphorylate other protein targets.**
- This statement is incorrect. DAG is involved in the activation of Protein Kinase C (PKC) rather than Ca++/Calmodulin-dependent kinases.
2. **DAG is in the cytoplasm and releases Ca2+ from the ER.**
- This statement is incorrect. DAG is typically localized to the plasma membrane.
3. **DAG binds to IP3 receptors.**
- This statement is incorrect. IP3 receptors are located on the endoplasmic reticulum and are specifically activated by Inositol trisphosphate (IP3), not DAG.
4. **DAG is in the plasma membrane and activates PKC.**
- This statement is correct. DAG is associated with the plasma membrane where it plays a role in the activation of Protein Kinase C (PKC), which is crucial for various cellular functions.
#### Correct Answer:
4. **DAG is in the plasma membrane and activates PKC.**
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