Which of the following has the secondary property of positive allosteric modulation at nicotinic receptors? A) Galantamine OB) Memantine OC) Donepezil OD) Rivastigmine
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- When an elderly but active gentleman came in to collect his prescription for zopiclone (3.75mg at night), he seemed anxious and asked if it was longer acting than lormetazepam, whichwas his last hypnotic.He had asked his GP to change to a longer acting hypnotic because he was waking up in themiddle of the night to go to the toilet, not able to go back to sleep. The two hypnotics havesimilar properties but if anything the duration of action of zopiclone is slightly shorter.• The gentleman is 72; he lost his wife 10 months ago and is now living with his daughter’sfamily. She has two teenage girls.1: What issues would you want to explore?2: What would your advice be?3: Why do you think the GP changed the hypnotics?Based on the transduction pathway presented above, what type of receptor is the beta-3 adrenergic receptor? Question 15 options: a) It is a voltage-dependent ion channel. b) It is a G protein-coupled receptor (GPCR). c) It is a G protein. d) It is a protein kinase. e) It is a receptor tyrosine kinase (RTK).In olfactory neurons, it is estimated that activation of the olfactory receptors results in an increase of roughly 200,000 molecules of cAMP per second. 1a) If an activated receptor produces one molecule of cAMP every 30 seconds, how many molecules of this receptor must be working in an activated neuron? How many G-alpha subunits are required in an activated neuron? 1b) If one receptor molecule is capable of activating 500 G-proteins, how many receptors will be activated?
- Which of the following statements is true? Select one: O a. Cholinergic nicotinic receptors of autonomic ganglia are identical to N cholinergic receptors of neuromuscular junction O b. Some of the postganglionic sympathetic fibers are cholinergic O c. All of the visceral organs/structures have dual innervation (sympathetic and parasympathetic) O d. Adrenaline does not usually circulate in bloodWhich of the following is true in regards to dopamine activity in the basal ganglia? (Select all that apply) Question 7 options: A) D1 receptors are coupled to the Gs subunit B) D2 receptors inhibit the indirect pathway C) D2 receptors are coupled to the Gi subunit D) D1 receptors activate the direct pathwayThe one i have to use to answer these questions are Prolactin please :)
- Atropine (I) and Ipratropium bromide (II) are both muscarinic acetylcholine receptor antagonists. Common side effects of atropine (1) include dizziness, blurred vision, and sedation. With Ipratropium bromide (II) these side effects are much less common. Given the two structures below, what might be the reason for the different side-effect profile of the two drugs? Br HO HOWhat is the muscarininc acetylcholine receptor? Where is it expressed?Suggest whether the following structures are likely to act as cholinergic agonists or not and briefly explain your reasons: A B CF
- Answer the following step by step A) How many milliliters of 1:100 epinephrine are needed for a 5 mg dose? B) How many milligrams are there in a 1cc dose of 2% Xylocaine? C)You have 20% acetylcysteine; how many milliliters do you need of this to form 4 ml of 8% solution?John Hughes and Hans Kosterlitz identified the endorphin receptor in frogs, and concluded that animals have a "built in" opioid system. To make sure that endorphins are truly neurochemicals, which of the following question should we ask these gentlemen? Please select all that apply.a) Are endorphins released in response to presynaptic depolarization? b) Do endorphins interact with postsynaptic receptors? c) Are endorphins found in presynaptic cells? d) Are endorphins subject to reuptake?Hemp oil has high CBD and low THC levels. It also shows promise in treating epilepsy. Based on what we learned, this doesn’t seem like an ideal formulation. (A) Why? (B) What might be a better treatment?