How can 5-HT2a activation be linked to dream-like experiences and hallucinations, but serotonin is low during REM sleep? Is it that although serotonin is low, of what is activated is the 5-HT2a receptor?
How can 5-HT2a activation be linked to dream-like experiences and hallucinations, but serotonin is low during REM sleep? Is it that although serotonin is low, of what is activated is the 5-HT2a receptor?
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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How can 5-HT2a activation be linked to dream-like experiences and hallucinations, but serotonin is low during REM sleep? Is it that although serotonin is low, of what is activated is the 5-HT2a receptor?
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Step 1: Introducing 5- HT2a
5- HT2a is a receptor antagonist it results in significant but differential regulation of mRNA levels in the hippocampus and neocortex.
Serotonin 5- HT2a receptor is a GPCR of type A family. It is both inhibitory and excitatory.
The receptors mediate effects of a large variety of compounds that affect depression, schizophrenia, hallucinations, sleep patters etc. Binding with the receptor subtype induces processes that regulate receptor sensitivity.
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