Which of the following claims is most consistent with the data shown ina.Esp protein does not regulate blood-sugar levels in normal mice. b.Normal mice require a higher blood concentration of insulin than mutant mice do. c.Esp expression is necessary to prevent the overproduction of insulin. d.Mutant mice have a cyclical pattern of insulin secretion. **Title: Comparative Analysis of Blood Insulin Levels in Normal and Esp Mutant Mice Post-Glucose Injection****Description:**This educational section presents a comparative analysis of blood insulin levels in normal mice and Esp (Ectopic P-glycoprotein) mutant mice, following their exposure to glucose injection. The graph illustrates the dynamic changes in blood insulin levels over a 60-minute period, offering insights into the metabolic differences between these two groups.**Figure 2:**- **Y-Axis:** The Y-axis represents the blood insulin concentration, measured in nanograms per milliliter (ng/mL), ranging from 0.2 to 1.2 ng/mL. - **X-Axis:** The X-axis represents time, measured in minutes after glucose injection, ranging from 0 to 60 minutes.The graph includes two distinct lines representing the data:1. **Normal Mice:** - Depicted with open circles connected by a solid line. - Blood insulin levels initially spike sharply within the first few minutes after glucose injection, reaching approximately 0.9 ng/mL. - This is followed by a decline and subsequent leveling off, maintaining a relatively constant level around 0.4 ng/mL from 20 to 60 minutes post-injection.2. **Esp Mutant Mice:** - Depicted with filled circles connected by a dashed line. - Blood insulin levels in mutant mice start around 0.4 ng/mL and show a more gradual increase over time. - Unlike in normal mice, insulin levels continue to rise, peaking at around 0.8 ng/mL by the 60-minute mark.The error bars on each data point indicate the variability and provide a sense of the precision of the measurements.**Analysis:**- The graph highlights a significant disparity in the insulin response between normal and Esp mutant mice, suggesting that Esp mutations may influence the regulation of insulin following glucose exposure.- Normal mice show a quick response with an initial spike in insulin levels, which then stabilizes, whereas mutant mice display a sustained increase over time.**Conclusion:**This study's results underscore the impact of genetic mutations on metabolic responses, offering valuable insights for further research on diabetes and other metabolic disorders. Understanding these differences is crucial for developing targeted treatments and therapies.

Hormones are the organic substances that are produced in small amounts by specific glands, which are…

Which of the following claims is most consistent with the data shown in a.Esp protein does not regulate blood-sugar levels in normal mice. b.Normal mice require a higher blood concentration of insulin than mutant mice do. c.Esp expression is necessary to prevent the overproduction of insulin. d.Mutant mice have a cyclical pattern of insulin secretion.

Which of the following claims is most consistent with the data shown in a.Esp protein does not regulate blood-sugar levels in normal mice. b.Normal mice require a higher blood concentration of insulin than mutant mice do. c.Esp expression is necessary to prevent the overproduction of insulin. d.Mutant mice have a cyclical pattern of insulin secretion.

Principles Of Pharmacology Med Assist

6th Edition

ISBN:9781337512442

Author:RICE

Publisher:RICE

Chapter21: Medications Used For Musculoskeletal System Disorders

Section: Chapter Questions

Problem 24RQ

See similar textbooks

Similar questions

Discuss the advantages and disadvantages of using genetic engineering to produce human insulin.
Please ignore the indented paragraph in the middle. What is the answer to this question?
What is an example of a biomolecule that interacts with Insulin? Please give a detailed explanation of that molecule's structure as well!
Question:- Write two paragraphs that describe how phosphofructokinase-1 and fructose 1,6-bisphosphatase are regulated in a coordinated and reciprocal manner. The first paragraph should describe how the enzymes are regulated in response to energy needs in muscle cells. The second paragraph should describe how the hormones glucagon and insulin exert their effects via fructose 2,6-bisphosphate in liver cells.
Despite the fact that many peptides have critical physiological functions(e.g., as hormones, neurotransmitters, antibacterial toxins), they are not considered to be ideal as drugs. The following questions illustrate some of the issues that limit the use of peptides as therapeutics.(a) Insulin is a peptide therapeutic used to manage Type 1 diabetes, whichaffects more than 20 million people worldwide according to the International Diabetes Federation. A significant limitation to the broad distribution and use of insulin to treat Type 1 diabetes is the fact that it must be administered by injection rather than orally. Why is insulin administered by injection and not orally?(b) Many of the D-amino acids found in nature have been discovered inbacterially produced peptides that have antibiotic properties. Bacteriasecrete these peptides into their environments to kill competitor bacteriaand thereby gain a selective advantage. Given your answer to part (a) ofthis question, what potential…
Please answer the following question: Answer the following questions about Glygogen Metabolism: (But DON’T Just think about glycogen here!) a. After a carbohydrate-filled breakfast, your blood glucose levels increase. How does glucose affect liver glycogen phosphorylase activity? Briefly explain the direct effect (i.e., not via hormones) glucose has on the enzyme, referring to the structure of the enzyme. b. Imagine you develop a drug that targets glycogen synthase kinase as a treatment for Type 2 diabetes. You need to determine if this drug activates or inhibits glycogen synthase kinase? What effect should the drug have on the phosphorylation state and activity of glycogen synthase? Explain in detail your decision. c. Would protein phosphatase 1 (PP1) have to be active or inactive for this drug to be effective? Explain the rationale for your response; be sure to refer to the function of PP1 in your response.
This is a Biochemistry Question! Please select all of the following processes that would INCREASE during untreated or badly managed diabetic ketoacidosis: (More than 1 answer) 1) there is fluid and electrolyte loss in urine 2) plasma pH 3) Glucose uptake & skeletal muscle using as primary fuel 4) Bicarbonate reabsorption & renal Hydrogen excretion 5) Relying on fatty acids & proteins as primary fuels throughout the body 6) Gluconeogenesis, Fatty acid oxidation, & ketogenesis (all within the liver) 7) Lipolysis & fatty acid release from adipose
Next, explain how three glut carriers [glut1, 2, and 4] effectively handle moving glucose into cellsbetween meals when blood sugar is at modest levels, and after a large meal when sugar blood levels spike. Make sure you define which glut carriers are found in which cell types, and howexcess sugars are stored in each of these cell types
From this discussion of the hormonal regulation of glycogen metabolism. Read this material and summarize in no more than one page. Use figures and frame your narrative in terms of the picture. No resources other than the text are required or desirable.
HbA1c is used to monitor blood glucose levels because hemoglobin is the only protein in blood that is covalently modified by glucose. True False Insulin Glargine is a long-acting form of insulin that is synthesized with several D-amino acids that slow its proteolytic degradation and extend the half-life of the insulin Glargine molecule. True False
Please answer asap and type your answer and do not copy from anywhere please
I need the answer as soon as possible