**Which DNA-damage repair pathway uses the BRCA1 and BRCA2 proteins?**This text is from a blank document interface on a laptop screen where the user is likely preparing to answer a question related to DNA repair mechanisms. **Context Explanation:**The BRCA1 and BRCA2 proteins are crucial components of the homologous recombination repair (HRR) pathway, which is a critical mechanism in repairing double-strand breaks in DNA. These proteins help maintain genomic stability by facilitating accurate DNA repair, thus preventing mutations that could lead to cancer. Understanding how these proteins function can lead to insights into genetic risk factors for certain types of cancer, such as breast and ovarian cancer.This question would be relevant to students or researchers studying genetics, molecular biology, or related fields.

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Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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**Which DNA-damage repair pathway uses the BRCA1 and BRCA2 proteins?**

This text is from a blank document interface on a laptop screen where the user is likely preparing to answer a question related to DNA repair mechanisms.

**Context Explanation:**

The BRCA1 and BRCA2 proteins are crucial components of the homologous recombination repair (HRR) pathway, which is a critical mechanism in repairing double-strand breaks in DNA. These proteins help maintain genomic stability by facilitating accurate DNA repair, thus preventing mutations that could lead to cancer. Understanding how these proteins function can lead to insights into genetic risk factors for certain types of cancer, such as breast and ovarian cancer.

This question would be relevant to students or researchers studying genetics, molecular biology, or related fields.

Expert Solution

BRCA1 and BRCA2 -

BRCA1 and BRCA2 are genes that encode tumor suppressor proteins. Whenever a DNA is damaged these proteins help the damaged DNA to get repaired to complete normal DNA synthesis and undergo a normal cell cycle. If there's a mutation in these genes then a cell will not be able to repair the damaged DNA and undergo an unregulated cell cycle hence becoming cancerous.

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