When chloroethane is treated with lithium metal, as shown below (step 1), an alkyllithium reagent A is produced The alkyllithium reagent A (two equivalent) reacts with copper(1) iodide in diethyl ether to give a Gilman reagent G (step 2) which in turn undergoes coouping reaction with chloropropane to give product P (step 3) (Textbook problem 10-11): CH3CH₂Cl 2A + Cul G + CH₂CH₂CH₂Cl 2Li pentane Ether Ether 0 °C The name of alkyllithium reagent A is Aan alkyllithium reagent G P a Gilman reagent
When chloroethane is treated with lithium metal, as shown below (step 1), an alkyllithium reagent A is produced The alkyllithium reagent A (two equivalent) reacts with copper(1) iodide in diethyl ether to give a Gilman reagent G (step 2) which in turn undergoes coouping reaction with chloropropane to give product P (step 3) (Textbook problem 10-11): CH3CH₂Cl 2A + Cul G + CH₂CH₂CH₂Cl 2Li pentane Ether Ether 0 °C The name of alkyllithium reagent A is Aan alkyllithium reagent G P a Gilman reagent
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Organomagnesium compounds
The interaction of alkyl halide with Mg metal in a suitable ether solvent is the common method for the synthesis of the Grignard reagent.
Hydrolysis Grignard Reactions and Reduction
Organomagnesium halides are Grignard reagents. Francois Auguste Victor Grignard, a French chemist who received the Nobel Prize in Chemistry in 1912, created these highly useful reagents.
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