What is the total yield of NADH, FADH2, and acetyl-CoA from the complete oxidation of myristate?  Assuming all of these metabolites are oxidized by the citrate cycle and oxidative phosphorylation, what is the net yield of ATP?

Biochemistry
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Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
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Fatty Oxidation and Ketogenesis

Q5.3:   What is the total yield of NADH, FADH2, and acetyl-CoA from the complete oxidation of myristate?  Assuming all of these metabolites are oxidized by the citrate cycle and oxidative phosphorylation, what is the net yield of ATP?

Expert Solution
Step 1

Myristic acid is a fatty acid with 14 carbon atoms.

Beta-oxidation is the oxidation of fatty acid on the beta-carbon atom, with the sequential removal of two carbon atoms in the form of acetyl CoA.

Three major steps involved in the beta-oxidation are:

  • Activation of fatty acid (in the cytosol)
  • Transport of fatty acid to the mitochondria.
  • Beta-oxidation in the mitochondrial matrix.

 

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