What is the major driving force that works in favor of tertiary protein structure formation (protein folding) and when does it occur (what are the conditions)?

Biochemistry
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ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
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What is the major driving force that works in favor of tertiary protein structure formation (protein folding) and when does it occur (what are the conditions)?

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Proteins are the complex macro molecules that show four levels of structural organisation. They are primary structure that consists of linear sequence of amino acids, secondary  structure that consists of alpha helices and beta sheets . Tertiary structure of protein is stabilised by hydrophobic and disulphide bonds and other weak interactions that are formed by further folding of secondary protein structure.

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