Answered: What do you predict that you would find…

Biology 2e

2nd Edition

ISBN:9781947172517

Author:Matthew Douglas, Jung Choi, Mary Ann Clark

Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark

Chapter16: Gene Expression

Section: Chapter Questions

Problem 18RQ: IS. Alternative splicing has been estimated to occur in more than 95% of multi-exon genes. Which of...

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Question

You take DNA samples from a family with a history of the genetic disease spinal muscular atrophy, which results from many different mutations in the SMA gene. One mutation in the SMA gene is a 240-bp in-frame deletion mutation in the middle of an exon. Data from this family shows you that several individuals from the family have this mutation. What do you predict that you would find when comparing the mRNA and protein products of the mutated and unmutated SMA gene? Select all that apply.

1. The mRNA from the SMA is more stable than unmutated SMA mRNA.

2. The pre-mRNA from the SMA mutant is shorter than the unmutated SMA pre-mRNA.

3. The mature mRNA from the SMA mutant is longer than the unmutated SMA mRNA.

4. The protein from the mutated SMA is shorter than the unmutated SMA protein.

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