Answered: What are the uses of NMR in new drug…

Chemistry In Focus

7th Edition

ISBN:9781337399692

Author:Tro, Nivaldo J.

Publisher:Tro, Nivaldo J.

Chapter17: Drugs And Medicine: Healing, Helping, And Hurting

Section: Chapter Questions

Problem 70E

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Which of the five dyes tested in this experiment has the strongest ability to absorb light? How do you know?
If the concentration of a food coloring solution is increased by a factor of 3, how will the absorbance change?
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5. A sample of a red dye and a sample of a blue dye both have the same concentration. Their Absorbance is measured using the same spectrophotometer. At a particular wavelength, will both samples give the same Absorbance reading? Why or why not?
What is the Rf value and what is the advantage of calculating Rf value? Explain.
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Many television crime shows depict forensic investigators using spectroscopy to detect the residue of bodily fluids at crime scenes. How does spectroscopy detect this residue?
Applications of NMR spectroscopy in pharmaceutical analysis Can potentially be used for fingerprinting mixtures Has good potential for non-destructive quantitative analysis of drugs in formulations without prior separation Can determine impurities, including enantiomeric impurities, without separation Powerfull technique for the characterization og the exact structure of raw materials, intermediates, and finished products
How can you distinguish aldehydes, ketones, and carboxylic acids from each other using IR spectra? Explain using specific examples.
Why were the absorbance measurements recorded at lambda max (504 nm)? Question 1 options: at lambda max impurities in the sample do not absorb any light Because the allura red dye absorbs red color at 504 nm at lambda max the absorbance is the most sensitive to dye concentration at lambda max the absorbance is the least sensitive to dye concentration
How many signals are greater than 100 ppm in the 13C NMR? How many signals are less than 100 ppm in the 13C NMR? How many total signals in the 13C NMR?
Describe the (general) relationship between the color of a pigment and the wavelength (and color) of light that it absorbs best

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What are the uses of NMR in new drug discoveries?