A. R OH SOCI₂ До R Cl NH3 / H₂O H₂N- H₂N- R གྱི R NH₂ HN R HN Anilides Heat a mixture of the acid (200 mg) and thionyl chloride (1 mL) in a test tube for 30 min in a 50 °C water bath. Cool the reaction in an ice bath and add 0.5 g of /anilide in 4 mL of toluene dropwise. Warm the mixture on the water bath for 2 min and wash with 1 mL portions of water, 5% HCl, 5% NaOH and another portion of water. Pipette out the organic (top) layer into a clean test tube after each washing step. The toluene is dried briefly over anhydrous calcium chloride pellets and evaporated in the hood. The derivative is recrystallized from water or ethanol-water. Cleaning up: Dilute the aqueous layers with water and place in aqueous waste. Place the drying agent in the hazardous waste container.

A. R OH SOCI₂ До R Cl NH3 / H₂O H₂N- H₂N- R གྱི R NH₂ HN R HN Anilides Heat a mixture of the acid (200 mg) and thionyl chloride (1 mL) in a test tube for 30 min in a 50 °C water bath. Cool the reaction in an ice bath and add 0.5 g of /anilide in 4 mL of toluene dropwise. Warm the mixture on the water bath for 2 min and wash with 1 mL portions of water, 5% HCl, 5% NaOH and another portion of water. Pipette out the organic (top) layer into a clean test tube after each washing step. The toluene is dried briefly over anhydrous calcium chloride pellets and evaporated in the hood. The derivative is recrystallized from water or ethanol-water. Cleaning up: Dilute the aqueous layers with water and place in aqueous waste. Place the drying agent in the hazardous waste container.

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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