VHL is a tumor suppressor because a. it causes cancer cells to become hypoxic b. it inhibits the enzyme proline hydroxylase c. it promotes the degradation of a powerful transcription factor. d. in the absence of VHL, HIF-1 is ubiquitylated by proline hydroxylase 2. NF-1 is a tumor suppressor because A. it inactivates Ras by promoting the hydrolysis of GTP to GDP B. it promotes the methylation of the Ras gene promoter C. it is a phosphatase that dephosphorylates the kinases in the Ras effector pathways D. it inhibits the GEF (guanine exchange factor) that activates Ras please answer both question cause this is my last posting question thank you
VHL is a tumor suppressor because a. it causes cancer cells to become hypoxic b. it inhibits the enzyme proline hydroxylase c. it promotes the degradation of a powerful transcription factor. d. in the absence of VHL, HIF-1 is ubiquitylated by proline hydroxylase 2. NF-1 is a tumor suppressor because A. it inactivates Ras by promoting the hydrolysis of GTP to GDP B. it promotes the methylation of the Ras gene promoter C. it is a phosphatase that dephosphorylates the kinases in the Ras effector pathways D. it inhibits the GEF (guanine exchange factor) that activates Ras please answer both question cause this is my last posting question thank you
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Question
1. VHL is a tumor suppressor because
| a. |
it causes cancer cells to become hypoxic
|
|
| b. |
it inhibits the enzyme proline hydroxylase
|
|
| c. |
it promotes the degradation of a powerful transcription factor.
|
|
| d. |
in the absence of VHL, HIF-1 is ubiquitylated by proline hydroxylase
|
2. NF-1 is a tumor suppressor because
| A. |
it inactivates Ras by promoting the hydrolysis of GTP to GDP
|
|
| B. |
it promotes the methylation of the Ras gene promoter
|
|
| C. |
it is a phosphatase that dephosphorylates the kinases in the Ras effector pathways
|
|
| D. |
it inhibits the GEF (guanine exchange factor) that activates Ras |
please answer both question cause this is my last posting question thank you
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