UVR Impact on 25(OH)D and CPD in Skin Types I-VI Skin type l-III 20 - 1.0 10- -0.5 -0.0 -10에 -0.5 20 40 60 80 % MED 25(OH)D CPD b Skin type IV-VI 20- 1.0 10- 0.5 Basal layer CPD level (AU) Basal layer a (7/owu) a(HO) abuey) (7/owu) alH
UVR Impact on 25(OH)D and CPD in Skin Types I-VI Skin type l-III 20 - 1.0 10- -0.5 -0.0 -10에 -0.5 20 40 60 80 % MED 25(OH)D CPD b Skin type IV-VI 20- 1.0 10- 0.5 Basal layer CPD level (AU) Basal layer a (7/owu) a(HO) abuey) (7/owu) alH
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
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Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Please explain the data
Transcribed Image Text:BB Shih et al.
UVR Impact on 25(OH)D and CPD in Skin Types I-VI
Skin type l-II
a
20-
1.0
10-
-0.5
0.0
-10-
-0.5
20
40
60
80
% MED
• 25(OH)D
- ČPD
Skin type IV-VI
20-
1.0
10-
-0.5
0.0
-10어
-0.5
20
40
60
80
% MED
Figure 3. Gain in basal layer CPD and 25(OH)D occurs concurrently in
lighter but not darker skin types. Assessment of epidermal CPD level in the
basal layer alone and serum 25(OH)D was performed in volunteers before
and after acute UVR exposures of 20%-80% of their individual sunburn
threshold (MED). (a) In lighter skin types (1-),a simultaneous increase in
serum 25(OH)D (n = 16–19 per dose) and CPD (n = 7-9 per dose) in the
germinative basal layer was seen across the UVR dose range. (b) In contrast,
in darker skin types (IV-VI), although a similar, significant UVR-25(OH)D
dose response occurred, basal layer CPD level remained undetectable across
the dose range (25(OH)D n = 17-19 per dose; CPD n = 3-5 volunteers per
dose). Individual volunteer data are shown. 25(OH)D, 25-hydroxyvitamin D;
AU, arbitrary unit; CPD, cyclobutane pyrimidine dimer; MED, minimal
erythema dose.
Basal layer CPD level (AU)
Basal layer CPD level (AU)
a (7/owu) al(HO)Sz uj ebueyO
Change in 25(OH)D (nmol/L)
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