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Using the information shown  in the image and the structural details of the K+ channel, answer and explain the following: A. Calculate the ratio (F1/F2) of the electrostatic force (F1) produced by the interaction between a K+cation and one O atom of a carbonyl in the selectivity filter, and the force (F2) between a Na+ cation and one O atom of a carbonyl in the selectivity filter. Use this ratio to explain why the channel is selective for K+ relative to Na+?

Using the information shown  in the image and the structural details of the K+ channel, answer and explain the following: A. Calculate the ratio (F1/F2) of the electrostatic force (F1) produced by the interaction between a K+cation and one O atom of a carbonyl in the selectivity filter, and the force (F2) between a Na+ cation and one O atom of a carbonyl in the selectivity filter. Use this ratio to explain why the channel is selective for K+ relative to Na+?

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Using the information shown  in the image and the structural details of the K+ channel, answer and explain the following:

A. Calculate the ratio (F1/F2) of the electrostatic force (F1) produced by the interaction between a K+cation and one O atom of a carbonyl in the selectivity filter, and the force (F2) between a Na+ cation and one O atom of a carbonyl in the selectivity filter. Use this ratio to explain why the channel is selective for K+ relative to Na+?

K* ionic radius = 1.33 Å Na* ionic radius = 0.95 Å Assume; q, for Nat = q2 for K* 3 Å 12 Å 34 Å +10 A-
Transcribed Image Text:K* ionic radius = 1.33 Å Na* ionic radius = 0.95 Å Assume; q, for Nat = q2 for K* 3 Å 12 Å 34 Å +10 A-
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