Unit 2. Homework: Synthesis and Sources of Ethers Draw all the products of the reactions to make ethers. 1) OH 140 °C Hx(O₂Si/Al)y + EtOH Hx(O₂Si/Al)y 2) 3) Draw the reactants to make the asymmetric ether product. tom OH 2,4,6-collidine nBu4N+PF6 3 Å mol sieves CH₂Cl₂ +CI-C, 10 mA 4) Give the best reaction conditions to synthesize n-butyl-t-butyl ether from t-butanol. (Hint: acidic conditions will give the volatile elimination product, isobutene. Why?)
Reactions of Ethers
Ethers (R-O-R’) are compounds formed by replacing hydrogen atoms of an alcohol (R-OH compound) or a phenol (C6H5OH) by an aryl/ acyl group (functional group after removing single hydrogen from an aromatic ring). In this section, reaction, preparation and behavior of ethers are discussed in the context of organic chemistry.
Epoxides
Epoxides are a special class of cyclic ethers which are an important functional group in organic chemistry and generate reactive centers due to their unusual high reactivity. Due to their high reactivity, epoxides are considered to be toxic and mutagenic.
Williamson Ether Synthesis
An organic reaction in which an organohalide and a deprotonated alcohol forms ether is known as Williamson ether synthesis. Alexander Williamson developed the Williamson ether synthesis in 1850. The formation of ether in this synthesis is an SN2 reaction.
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