You want to develop a drug that specifically kills cancer cells. Knowing about the Warburg effect, youhypothesize that cancer cells may be especially sensitive to inhibitors of glycolysis because they areuniquely dependent upon a high rate of glycolysis. Which one would be a good target for drugdevelopment?A. Acetyl CoAB. Isocitrate dehydrogenaseC. Pyruvate kinaseD. The electron-transport chain

Glycolysis is the breakdown of glucose into pyruvate (aerobic) or lactate (anaerobic). In Warburg…

Answered: uniquely dependent upon a high rate of…

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Biochemistry

uniquely dependent upon a high rate of glycolysis. Which one would be a good target for drug development?

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Concept explainers

Pharmacokinetics

Pharmacokinetics is made up of two words: pharmakon means drug, and kinetics which means moving. Pharmacokinetics could be defined in simple words as the movement of drugs through the whole body and out of the body.

Question

You want to develop a drug that specifically kills cancer cells. Knowing about the Warburg effect, you
hypothesize that cancer cells may be especially sensitive to inhibitors of glycolysis because they are
uniquely dependent upon a high rate of glycolysis. Which one would be a good target for drug
development?
A. Acetyl CoA
B. Isocitrate dehydrogenase
C. Pyruvate kinase
D. The electron-transport chain

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