Compared to the rectal and vaginal routes.   If an active substance has a high logP, this constitutes a limiting factor for bioavailability when formulated in a hydrophobic base. Briefly explain why.

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Compared to the rectal and vaginal routes.

 

If an active substance has a high logP, this constitutes a limiting factor for bioavailability when formulated in a hydrophobic base. Briefly explain why.

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